Metabolic profiling of plasma from discordant schizophrenia twins: Correlation between lipid signals and global functioning in female schizophrenia patients

Tsz M. Tsang; Jeffrey T.J. Huang; Elaine Holmes; Sabine Bahn

doi:10.1021/pr0503782

Metabolic profiling of plasma from discordant schizophrenia twins: Correlation between lipid signals and global functioning in female schizophrenia patients

Tsz M. Tsang, Jeffrey T.J. Huang, Elaine Holmes, Sabine Bahn

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

¹H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.

Original language	English
Pages (from-to)	756-760
Number of pages	5
Journal	Journal of Proteome Research
Volume	5
Issue number	4
Early online date	11 Mar 2006
DOIs	https://doi.org/10.1021/pr0503782
Publication status	Published - Apr 2006

Keywords

Global functioning score
LDL
Lipid
Metabolic profiling
Schizophrenia
VLDL

ASJC Scopus subject areas

Biochemistry
General Chemistry

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10.1021/pr0503782

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abstract = "1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.",

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AU - Holmes, Elaine

AU - Bahn, Sabine

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N2 - 1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.

AB - 1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.

KW - Global functioning score

KW - LDL

KW - Lipid

KW - Metabolic profiling

KW - Schizophrenia

KW - VLDL

U2 - 10.1021/pr0503782

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Metabolic profiling of plasma from discordant schizophrenia twins: Correlation between lipid signals and global functioning in female schizophrenia patients

Abstract

Keywords

ASJC Scopus subject areas

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