Metabolic profiling of plasma from discordant schizophrenia twins: Correlation between lipid signals and global functioning in female schizophrenia patients

Tsz M. Tsang, Jeffrey T.J. Huang, Elaine Holmes, Sabine Bahn

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.

    Original languageEnglish
    Pages (from-to)756-760
    Number of pages5
    JournalJournal of Proteome Research
    Volume5
    Issue number4
    Early online date11 Mar 2006
    DOIs
    Publication statusPublished - Apr 2006

    Keywords

    • Global functioning score
    • LDL
    • Lipid
    • Metabolic profiling
    • Schizophrenia
    • VLDL

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