Metabolic synergies in the biotransformation of organic and metallic toxic compounds by a saprotrophic soil fungus

Andrea Ceci, Flavia Pinzari, Carmela Riccardi, Oriana Maggi, Lucia Pierro, Marco Petrangeli Papini, Geoffrey Michael Gadd, Anna Maria Persiani (Lead / Corresponding author)

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Abstract

The saprotrophic fungus Penicillium griseofulvum was chosen as model organism to study responses to a mixture of hexachlorocyclohexane (HCH) isomers (α-HCH, β-HCH, γ-HCH, δ-HCH) and potentially toxic metals (vanadium, lead) in solid and liquid media. The P. griseofulvum FBL 500 strain was isolated from polluted soil containing high concentrations of HCH isomers and potentially toxic elements (Pb, V). Experiments were performed in order to analyse the tolerance/resistance of this fungus to xenobiotics and to shed further light on fungal potential in inorganic and organic biotransformations. The aim was to examine the ecological and bioremedial potential of this fungus verifying the presence of mechanisms that allow it to transform HCH isomers and metals under different extreme test conditions. To our knowledge, this work is the first to provide evidence on the biotransformation of HCH mixtures, in combination with toxic metals, by a saprotrophic non-white-rot fungus and on the metabolic synergies involved.

Original languageEnglish
Pages (from-to)1019-1033
Number of pages15
JournalApplied Microbiology and Biotechnology
Volume102
Issue number2
Early online date14 Nov 2017
DOIs
Publication statusPublished - 1 Jan 2018

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Keywords

  • Biotransformation
  • Hexachlorocyclohexane
  • Medium pH
  • Metabolic phenotype
  • Soil saprotrophic fungi
  • Vanadium

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