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Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes
Laura Hedges
, Susan Brown (Lead / Corresponding author)
,
A. Kenneth MacLeod
, Marjory Moreau
, Miyoung Yoon
, Moire R. Creek
, Thomas G. Osimitz
, Brian G. Lake
Drug Discovery Unit
Research output
:
Contribution to journal
›
Article
›
peer-review
13
Citations (Scopus)
Overview
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Dive into the research topics of 'Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes'. Together they form a unique fingerprint.
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Keyphrases
Metabolism
100%
Human Cytochrome P450
100%
Cytochrome P450 Enzymes
100%
Cyhalothrin
100%
Carboxylesterase Enzyme
100%
Bifenthrin
100%
Cyphenothrin
100%
Esfenvalerate
100%
Cyfluthrin
100%
Pyrethroids
77%
Aged Rats
22%
Sprague-Dawley Rats
11%
Species Differences
11%
Hepatic Cytochrome P450
11%
Adult Humans
11%
Human Liver Cytosol
11%
Male Rats
11%
Liver Microsomes
11%
Human Plasma
11%
Human Liver Microsomes
11%
Hepatic Clearance
11%
Rat Plasma
11%
Intrinsic Clearance
11%
Liver Cytosol
11%
Clearance Value
11%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
Carboxylesterase
100%
Cyphenothrin
100%
Cyhalothrin
100%
Cyfluthrin
100%
Bifenthrin
100%
Fenvalerate
100%
Pyrethroid
77%
Sprague Dawley Rat
11%
Intrinsic Clearance
11%