Metabolism of inflammation limited by AMPK and pseudo-starvation

L.A.J. O'Neill (Lead / Corresponding author), D. Grahame Hardie

    Research output: Contribution to journalArticle

    602 Citations (Scopus)

    Abstract

    Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1ß and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
    Original languageEnglish
    Pages (from-to)346-355
    Number of pages10
    JournalNature
    Volume493
    Issue number7432
    DOIs
    Publication statusPublished - 17 Jan 2013

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