Metabolism of inflammation limited by AMPK and pseudo-starvation

TY - JOUR

T1 - Metabolism of inflammation limited by AMPK and pseudo-starvation

AU - O'Neill, L.A.J.

AU - Hardie, D. Grahame

N1 - Work in the D.G.H. laboratory is supported by the Wellcome Trust and Cancer Research UK. Work in the L.O.N. laboratory is supported by Science Foundation Ireland and the European Research Council.

PY - 2013/1/17

Y1 - 2013/1/17

N2 - Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1ß and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.

AB - Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1ß and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.

UR - https://www.scopus.com/pages/publications/84872576236

U2 - 10.1038/nature11862

DO - 10.1038/nature11862

M3 - Article

AN - SCOPUS:84872576236

SN - 0028-0836

VL - 493

SP - 346

EP - 355

JO - Nature

JF - Nature

IS - 7432

ER -