Metal and Metal Oxide Nanoparticle-incorporated Polymer Nanofibers for Wound Healing

TY - CHAP

T1 - Metal and Metal Oxide Nanoparticle-incorporated Polymer Nanofibers for Wound Healing

AU - dos Santos, Vivian Inês

AU - Homaeigohar, Shahin

AU - Boccaccini, Aldo Roberto

N1 - © The Royal Society of Chemistry 2025 All rights reserved

PY - 2025/12/15

Y1 - 2025/12/15

N2 - This chapter presents an in-depth overview of polymer nanofibers incorporated with metal and metal oxide nanoparticles for wound healing applications. It begins by outlining the fundamentals of wound healing and the limitations of conventional wound dressings. The electrospinning technique is then introduced as a versatile method for fabricating nanofibrous scaffolds that closely mimic the extracellular matrix, offering enhanced porosity, surface area, and mechanical properties ideal for wound care. This chapter extensively examines the role of metal nanoparticles (AgNPs, CuNPs, AuNPs) and metal oxide nanoparticles (ZnO NPs, TiO2 NPs, Fe3O4 NPs) in enhancing the antibacterial, antioxidant, pro-angiogenic, and anti-inflammatory properties of nanofibrous wound dressings. The mechanisms by which these nanoparticles exert antimicrobial activity – such as reactive oxygen species (ROS) generation, membrane disruption, and metal ion release – are detailed. Furthermore, the chapter analyzes how the incorporation of nanoparticles influences the physicochemical properties of nanofibers, as well as the associated challenges, including cytotoxicity, aggregation, stability, scalability, and regulatory barriers. Future perspectives highlight the potential of greener synthesis methods, the use of biocompatible reducing and stabilizing agents, and the development of synergistic nanoparticle combinations to enhance therapeutic outcomes while mitigating toxicity. This chapter serves as a comprehensive guide for advancing the design of multifunctional wound dressings that address current clinical challenges.

AB - This chapter presents an in-depth overview of polymer nanofibers incorporated with metal and metal oxide nanoparticles for wound healing applications. It begins by outlining the fundamentals of wound healing and the limitations of conventional wound dressings. The electrospinning technique is then introduced as a versatile method for fabricating nanofibrous scaffolds that closely mimic the extracellular matrix, offering enhanced porosity, surface area, and mechanical properties ideal for wound care. This chapter extensively examines the role of metal nanoparticles (AgNPs, CuNPs, AuNPs) and metal oxide nanoparticles (ZnO NPs, TiO2 NPs, Fe3O4 NPs) in enhancing the antibacterial, antioxidant, pro-angiogenic, and anti-inflammatory properties of nanofibrous wound dressings. The mechanisms by which these nanoparticles exert antimicrobial activity – such as reactive oxygen species (ROS) generation, membrane disruption, and metal ion release – are detailed. Furthermore, the chapter analyzes how the incorporation of nanoparticles influences the physicochemical properties of nanofibers, as well as the associated challenges, including cytotoxicity, aggregation, stability, scalability, and regulatory barriers. Future perspectives highlight the potential of greener synthesis methods, the use of biocompatible reducing and stabilizing agents, and the development of synergistic nanoparticle combinations to enhance therapeutic outcomes while mitigating toxicity. This chapter serves as a comprehensive guide for advancing the design of multifunctional wound dressings that address current clinical challenges.

U2 - 10.1039/9781837677627-00100

DO - 10.1039/9781837677627-00100

M3 - Chapter (peer-reviewed)

SN - 9781837673742

T3 - Nanoscience & Nanotechnology Series

SP - 100

EP - 178

BT - Hybrid and Composite Nanofibrous Materials for Wound Healing Applications

A2 - Homaeigohar, Shahin

A2 - Roether, Judith A.

A2 - Boccaccini, Aldo R.

PB - Royal Society of Chemistry

ER -