Metformin-Acting through Cyclic AMP as well as AMP?

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    14 Citations (Scopus)


    Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.

    Original languageEnglish
    Pages (from-to)313-4
    Number of pages2
    JournalCell Metabolism
    Issue number3
    Publication statusPublished - 5 Mar 2013


    • Journal Article


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