Metformin-Acting through Cyclic AMP as well as AMP?

D Grahame Hardie

doi:10.1016/j.cmet.2013.02.011

Metformin-Acting through Cyclic AMP as well as AMP?

D Grahame Hardie

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.

Original language	English
Pages (from-to)	313-4
Number of pages	2
Journal	Cell Metabolism
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2013.02.011
Publication status	Published - 5 Mar 2013

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cmet.2013.02.011

Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)
Hardie, G. (Investigator)
1/04/12 → 30/09/17
Project: Research

Cite this

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title = "Metformin-Acting through Cyclic AMP as well as AMP?",

abstract = "Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.",

keywords = "Journal Article",

author = "Hardie, {D Grahame}",

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year = "2013",

month = mar,

day = "5",

doi = "10.1016/j.cmet.2013.02.011",

language = "English",

volume = "17",

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journal = "Cell Metabolism",

issn = "1550-4131",