Metformin-Acting through Cyclic AMP as well as AMP?

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.

    Original languageEnglish
    Pages (from-to)313-4
    Number of pages2
    JournalCell Metabolism
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - 5 Mar 2013

    Fingerprint

    Metformin
    Therapeutic Uses
    Adenosine Monophosphate
    Glucagon
    Cyclic AMP
    Type 2 Diabetes Mellitus
    Glucose
    Liver
    Pharmaceutical Preparations

    Keywords

    • Journal Article

    Cite this

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    title = "Metformin-Acting through Cyclic AMP as well as AMP?",
    abstract = "Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.",
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    Metformin-Acting through Cyclic AMP as well as AMP? / Hardie, D Grahame.

    In: Cell Metabolism, Vol. 17, No. 3, 05.03.2013, p. 313-4.

    Research output: Contribution to journalArticle

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