Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes

Keyphrases

• Chitin Synthesis Inhibitor 100%
• Family 18 chitinase 100%
• Binding Mode 100%
• Mode of Inhibition 100%
• Methylxanthines 100%
• Pentoxifylline 100%
• Mutagenesis 50%
• Lung 50%
• Mechanism of Action 50%
• Active Sites 50%
• Allosamidin 50%
• Crystallographic Analysis 50%
• Specific Interactions 50%
• Marketed Drugs 50%
• Caffeine 50%
• Binding Residues 50%
• Inhibitor Complex 50%
• Anti-inflammatory Agents 50%
• Asthmatic 50%
• Competitive Inhibitor 50%
• Pathogenic Organisms 50%
• Enzyme Assay 50%
• Mammalian chitinase 50%
• Human chitinase 50%
• Reaction Intermediates 50%
• Theophylline 50%
• Drug Molecules 50%
• Methylxanthine Derivatives 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Chitinase 100%
• Methylxanthine 100%
• Pentoxifylline 33%
• Mutagenesis 16%
• Antiinflammatory Agent 16%
• Competitive Inhibitor 16%
• Allosamidin 16%
• Methylxanthine Derivative 16%
• Theophylline Derivative 16%

Biochemistry, Genetics and Molecular Biology

• Chitinase 100%
• Active Site 33%
• Pentoxifylline 33%
• Mutagenesis 16%
• Competitive Inhibition 16%
• Enzyme Assay 16%
• Theophylline 16%