METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over

Stuart Taylor; Susan Mallett; Gauraang Bhatnagar; Stuart Bloom; Arun Gupta; Steve Halligan; John Hamlin; Ailsa Hart; Antony Higginson; Ilan Jacobs; Sara McCartney; Steve Morris; Nicola Muirhead; Charles Murray; Shonit Punwani; Manuel Rodriguez-Justo; Andrew Slater; Simon Travis; Damian Tolan; Alastair Windsor; Peter Wylie; Ian Zealley

doi:10.1186/1471-230X-14-142

METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over

Stuart Taylor (Lead / Corresponding author), Susan Mallett, Gauraang Bhatnagar, Stuart Bloom, Arun Gupta, Steve Halligan, John Hamlin, Ailsa Hart, Antony Higginson, Ilan Jacobs, Sara McCartney, Steve Morris, Nicola Muirhead, Charles Murray, Shonit Punwani, Manuel Rodriguez-Justo, Andrew Slater, Simon Travis, Damian Tolan, Alastair WindsorPeter Wylie, Ian Zealley

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Abstract

Crohn's disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging is crucial for diagnosis, phenotyping, activity assessment and detecting complications. Diverse small bowel imaging tests are available but a standard algorithm for deployment is lacking. Many hospitals employ tests that impart ionising radiation, of particular concern to this young patient population. Magnetic resonance enterography (MRE) and small bowel ultrasound (USS) are attractive options, as they do not use ionising radiation. However, their comparative diagnostic accuracy has not been compared in large head to head trials. METRIC aims to compare the diagnostic efficacy, therapeutic impact and cost effectiveness of MRE and USS in newly diagnosed and relapsing CD.

Original language	English
Pages (from-to)	142
Number of pages	10
Journal	BMC Gastroenterology
Volume	14
DOIs	https://doi.org/10.1186/1471-230X-14-142
Publication status	Published - 11 Aug 2014

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10.1186/1471-230X-14-142Licence: CC BY

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© 2014 Taylor et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Taylor, S., Mallett, S., Bhatnagar, G., Bloom, S., Gupta, A., Halligan, S., Hamlin, J., Hart, A., Higginson, A., Jacobs, I., McCartney, S., Morris, S., Muirhead, N., Murray, C., Punwani, S., Rodriguez-Justo, M., Slater, A., Travis, S., Tolan, D., ... Zealley, I. (2014). METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over. BMC Gastroenterology, 14, 142. https://doi.org/10.1186/1471-230X-14-142

Taylor, Stuart ; Mallett, Susan ; Bhatnagar, Gauraang et al. / METRIC (MREnterography or ulTRasound in Crohn's disease) : a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over. In: BMC Gastroenterology. 2014 ; Vol. 14. pp. 142.

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title = "METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over",

abstract = "Crohn's disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging is crucial for diagnosis, phenotyping, activity assessment and detecting complications. Diverse small bowel imaging tests are available but a standard algorithm for deployment is lacking. Many hospitals employ tests that impart ionising radiation, of particular concern to this young patient population. Magnetic resonance enterography (MRE) and small bowel ultrasound (USS) are attractive options, as they do not use ionising radiation. However, their comparative diagnostic accuracy has not been compared in large head to head trials. METRIC aims to compare the diagnostic efficacy, therapeutic impact and cost effectiveness of MRE and USS in newly diagnosed and relapsing CD.",

author = "Stuart Taylor and Susan Mallett and Gauraang Bhatnagar and Stuart Bloom and Arun Gupta and Steve Halligan and John Hamlin and Ailsa Hart and Antony Higginson and Ilan Jacobs and Sara McCartney and Steve Morris and Nicola Muirhead and Charles Murray and Shonit Punwani and Manuel Rodriguez-Justo and Andrew Slater and Simon Travis and Damian Tolan and Alastair Windsor and Peter Wylie and Ian Zealley",

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doi = "10.1186/1471-230X-14-142",

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Taylor, S, Mallett, S, Bhatnagar, G, Bloom, S, Gupta, A, Halligan, S, Hamlin, J, Hart, A, Higginson, A, Jacobs, I, McCartney, S, Morris, S, Muirhead, N, Murray, C, Punwani, S, Rodriguez-Justo, M, Slater, A, Travis, S, Tolan, D, Windsor, A, Wylie, P & Zealley, I 2014, 'METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over', BMC Gastroenterology, vol. 14, pp. 142. https://doi.org/10.1186/1471-230X-14-142

METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over. / Taylor, Stuart (Lead / Corresponding author); Mallett, Susan; Bhatnagar, Gauraang et al.
In: BMC Gastroenterology, Vol. 14, 11.08.2014, p. 142.

Research output: Contribution to journal › Article › peer-review

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T1 - METRIC (MREnterography or ulTRasound in Crohn's disease)

T2 - a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over

AU - Taylor, Stuart

AU - Mallett, Susan

AU - Bhatnagar, Gauraang

AU - Bloom, Stuart

AU - Gupta, Arun

AU - Halligan, Steve

AU - Hamlin, John

AU - Hart, Ailsa

AU - Higginson, Antony

AU - Jacobs, Ilan

AU - McCartney, Sara

AU - Morris, Steve

AU - Muirhead, Nicola

AU - Murray, Charles

AU - Punwani, Shonit

AU - Rodriguez-Justo, Manuel

AU - Slater, Andrew

AU - Travis, Simon

AU - Tolan, Damian

AU - Windsor, Alastair

AU - Wylie, Peter

AU - Zealley, Ian

PY - 2014/8/11

Y1 - 2014/8/11

N2 - Crohn's disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging is crucial for diagnosis, phenotyping, activity assessment and detecting complications. Diverse small bowel imaging tests are available but a standard algorithm for deployment is lacking. Many hospitals employ tests that impart ionising radiation, of particular concern to this young patient population. Magnetic resonance enterography (MRE) and small bowel ultrasound (USS) are attractive options, as they do not use ionising radiation. However, their comparative diagnostic accuracy has not been compared in large head to head trials. METRIC aims to compare the diagnostic efficacy, therapeutic impact and cost effectiveness of MRE and USS in newly diagnosed and relapsing CD.

AB - Crohn's disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging is crucial for diagnosis, phenotyping, activity assessment and detecting complications. Diverse small bowel imaging tests are available but a standard algorithm for deployment is lacking. Many hospitals employ tests that impart ionising radiation, of particular concern to this young patient population. Magnetic resonance enterography (MRE) and small bowel ultrasound (USS) are attractive options, as they do not use ionising radiation. However, their comparative diagnostic accuracy has not been compared in large head to head trials. METRIC aims to compare the diagnostic efficacy, therapeutic impact and cost effectiveness of MRE and USS in newly diagnosed and relapsing CD.

U2 - 10.1186/1471-230X-14-142

DO - 10.1186/1471-230X-14-142

M3 - Article

C2 - 25110044

SN - 1471-230X

VL - 14

SP - 142

JO - BMC Gastroenterology

JF - BMC Gastroenterology

ER -

Taylor S, Mallett S, Bhatnagar G, Bloom S, Gupta A, Halligan S et al. METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over. BMC Gastroenterology. 2014 Aug 11;14:142. doi: 10.1186/1471-230X-14-142