Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

Simon Chang; Lars Iversen; Knud Kragballe; J. Simon C. Arthur; Claus Johansen

doi:10.3109/07357907.2010.550594

Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

Simon Chang, Lars Iversen, Knud Kragballe, J. Simon C. Arthur, Claus Johansen

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.</.

Original language	English
Pages (from-to)	240-245
Number of pages	6
Journal	Cancer Investigation
Volume	29
Issue number	3
DOIs	https://doi.org/10.3109/07357907.2010.550594
Publication status	Published - Mar 2011

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title = "Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model",

abstract = "Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.</.",

author = "Simon Chang and Lars Iversen and Knud Kragballe and Arthur, {J. Simon C.} and Claus Johansen",

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T1 - Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

AU - Chang, Simon

AU - Iversen, Lars

AU - Kragballe, Knud

AU - Arthur, J. Simon C.

AU - Johansen, Claus

PY - 2011/3

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N2 - Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.</.

AB - Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.</.

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JO - Cancer Investigation

JF - Cancer Investigation

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Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

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