Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

TY - JOUR

T1 - Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

AU - Chang, Simon

AU - Iversen, Lars

AU - Kragballe, Knud

AU - Arthur, J. Simon C.

AU - Johansen, Claus

PY - 2011/3

Y1 - 2011/3

N2 - Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.

AB - Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.

U2 - 10.3109/07357907.2010.550594

DO - 10.3109/07357907.2010.550594

M3 - Article

C2 - 21314333

SN - 0735-7907

VL - 29

SP - 240

EP - 245

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -