Abstract
This paper describes the design and simulation of an integrated micro-electro-mechanical system (MEMS) to be used for small scale tissue manipulation. The micro-grippers are to be used to test the mechanical cell adhesion properties of the gut epithelium. In the majority of sporadic colon cancers the Adenomatous Polyopsis Coli (APC) protein is mutated or missing. Mutations of APC occur extremely early in the development of cancer, before formation of polyps. Micro-grippers were designed and finite element analysis (FEA) was used to find actuation displacements, tip temperature and stresses. Monolayers of gut epithelial tissue will be grown on collagen substrates and stretched under tensile force. Ni micro-grippers will be used to grip the substrate due to its high gripping stiffness and force resolution. SU-8 micro-grippers will be used to directly grip on cell membrane to analyze cell adhesion forces with APC present or absent. The following paper shows the design of the system and FEA of micro-grippers.
Original language | English |
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Title of host publication | IFMBE Proceedings |
Subtitle of host publication | 4th European Conference of the International Federation for Medical and Biological Engineering |
Editors | J. Vander Sloten, P. Verdonck, M. Nyssen, J. Haueisen |
Place of Publication | New York |
Publisher | Springer |
Pages | 2619-2622 |
Number of pages | 4 |
Volume | 22 |
ISBN (Print) | 978-3-540-89207-6 |
DOIs | |
Publication status | Published - 2009 |
Event | 4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgium Duration: 23 Nov 2008 → 27 Nov 2008 |
Conference
Conference | 4th European Conference of the International Federation for Medical and Biological Engineering |
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Country/Territory | Belgium |
City | Antwerp |
Period | 23/11/08 → 27/11/08 |