Microbial biofilms and gastrointestinal diseases

Erik C. von Rosenvinge, Graeme A. O'May, Sandra Macfarlane, George T. Macfarlane, Mark E. Shirtliff

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    30 Citations (Scopus)

    Abstract

    The majority of bacteria live not planktonically, but as residents of sessile biofilm communities. Such populations have been defined as 'matrix-enclosed microbial accretions, which adhere to both biological and nonbiological surfaces'. Bacterial formation of biofilm is implicated in many chronic disease states. Growth in this mode promotes survival by increasing community recalcitrance to clearance by host immune effectors and therapeutic antimicrobials. The human gastrointestinal (GI) tract encompasses a plethora of nutritional and physicochemical environments, many of which are ideal for biofilm formation and survival. However, little is known of the nature, function, and clinical relevance of these communities. This review summarizes current knowledge of the composition and association with health and disease of biofilm communities in the GI tract.

    Original languageEnglish
    Pages (from-to)25-38
    Number of pages14
    JournalPathogens and Disease
    Volume67
    Issue number1
    DOIs
    Publication statusPublished - Feb 2013

    Keywords

    • gastrointestinal tract
    • BARRETTS-ESOPHAGUS
    • HELICOBACTER-PYLORI INFECTION
    • PERCUTANEOUS ENDOSCOPIC GASTROSTOMY
    • INVASIVE ESCHERICHIA-COLI
    • CROHNS-DISEASE
    • INTESTINAL BACTERIA
    • microbiota
    • HUMAN GASTRIC-MUCOSA
    • EXPERIMENTAL ULCERATIVE-COLITIS
    • biofilm
    • INFLAMMATORY-BOWEL-DISEASE
    • GASTROESOPHAGEAL REFLUX DISEASE
    • gastrointestinal disease

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