@article{de915905d8c140b38b28d89ba88214f2,
title = "Microglial control of neuronal development via somatic purinergic junctions",
abstract = "Microglia, the resident immune cells of the brain, play important roles during development. Although bi-directional communication between microglia and neuronal progenitors or immature neurons has been demonstrated, the main sites of interaction and the underlying mechanisms remain elusive. By using advanced methods, here we provide evidence that microglial processes form specialized contacts with the cell bodies of developing neurons throughout embryonic, early postnatal, and adult neurogenesis. These early developmental contacts are highly reminiscent of somatic purinergic junctions that are instrumental for microglia-neuron communication in the adult brain. The formation and maintenance of these junctions is regulated by functional microglial P2Y12 receptors, and deletion of P2Y12Rs disturbs proliferation of neuronal precursors and leads to aberrant cortical cytoarchitecture during development and in adulthood. We propose that early developmental formation of somatic purinergic junctions represents an important interface for microglia to monitor the status of immature neurons and control neurodevelopment.",
keywords = "CP: Neuroscience, doublecortin, microglia, neuronal development, P2Y12R, purinergic, somatic junction",
author = "Csaba Cser{\'e}p and Schwarcz, {Anett D.} and Bal{\'a}zs P{\'o}sfai and L{\'a}szl{\'o}, {Zs{\'o}fia I.} and Anna Kellermayer and Zsuzsanna K{\"o}rnyei and M{\'a}t{\'e} Kisfali and Mikl{\'o}s Nyerges and Zsolt Lele and Istv{\'a}n Katona and {{\'A}d{\'a}m D{\'e}nes}, D{\'e}nes",
note = "Funding Information: We thank Drs. L{\'a}szl{\'o} Barna and P{\'a}l V{\'a}gi for kindly providing microscopy support and D{\'o}ra Gali-Gy{\"o}rkei, Bal{\'a}zs Pint{\'e}r, and Erika Tischler for excellent technical assistance. The study was supported by “ Momentum ” research grants from the Hungarian Academy of Sciences ( LP2016-4/2016 and LP2022-5/2022 to {\'A}.D.), ERC-CoG 724994 (to {\'A}.D.), the J{\'a}nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (to C.C.), {\'U}NKP-20-3-II and {\'U}NKP-21-4 (to B.P.) and {\'U}NKP-20-5 and {\'U}NKP-21-5 (to C.C.), the New National Excellence Program of the Ministry for Innovation and Technology , the Gedeon Richter's Talentum Foundation (to A.D.S.), and by 2020-1.2.4-T{\'E}T-IPARI-2021-00005 (to {\'A}.D.). I.K. was supported by the National Brain Research Program ( 2017-1.2.1-NKP-2017-00002 ) and by the National Research, Development and Innovation Office , Hungary (Frontier Program 129961). The funding institutions had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = sep,
day = "20",
doi = "10.1016/j.celrep.2022.111369",
language = "English",
volume = "40",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier",
number = "12",
}