Microultraound and small bowel inflammation: Tissue phantom studies

Benjamin F. Cox; Vipin Seetohul; Holly Lay; Sandy Cochran

doi:10.1109/ULTSYM.2015.0304

Microultraound and small bowel inflammation: Tissue phantom studies

Benjamin F. Cox (Lead / Corresponding author), Vipin Seetohul, Holly Lay, Sandy Cochran

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

282 Downloads (Pure)

Abstract

Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.

Original language	English
Title of host publication	2015 IEEE International Ultrasonics Symposium, IUS 2015
Publisher	Institute of Electrical and Electronics Engineers
ISBN (Print)	9781479981823
DOIs	https://doi.org/10.1109/ULTSYM.2015.0304
Publication status	Published - 13 Nov 2015
Event	IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: 21 Oct 2015 → 24 Oct 2015

Conference

Conference	IEEE International Ultrasonics Symposium, IUS 2015
Country/Territory	Taiwan, Province of China
City	Taipei
Period	21/10/15 → 24/10/15

Keywords

Capsule Endoscopy
Inflammation
Leukocytes
Microultrasound
Small Bowel

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2015.0304

Microultraound and Small Bowel Inflamation Phantom Studies (Full)Accepted author manuscript, 430 KB

Cite this

@inproceedings{00ef910bcf6d423494facee7a6218ebf,

title = "Microultraound and small bowel inflammation: Tissue phantom studies",

abstract = "Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.",

keywords = "Capsule Endoscopy, Inflammation, Leukocytes, Microultrasound, Small Bowel",

author = "Cox, {Benjamin F.} and Vipin Seetohul and Holly Lay and Sandy Cochran",

year = "2015",

month = nov,

day = "13",

doi = "10.1109/ULTSYM.2015.0304",

language = "English",

isbn = "9781479981823",

booktitle = "2015 IEEE International Ultrasonics Symposium, IUS 2015",

publisher = "Institute of Electrical and Electronics Engineers",

note = "IEEE International Ultrasonics Symposium, IUS 2015 ; Conference date: 21-10-2015 Through 24-10-2015",

}

Cox, BF, Seetohul, V, Lay, H & Cochran, S 2015, Microultraound and small bowel inflammation: Tissue phantom studies. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329307, Institute of Electrical and Electronics Engineers, IEEE International Ultrasonics Symposium, IUS 2015, Taipei, Taiwan, Province of China, 21/10/15. https://doi.org/10.1109/ULTSYM.2015.0304

TY - GEN

T1 - Microultraound and small bowel inflammation

T2 - IEEE International Ultrasonics Symposium, IUS 2015

AU - Cox, Benjamin F.

AU - Seetohul, Vipin

AU - Lay, Holly

AU - Cochran, Sandy

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.

AB - Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.

KW - Capsule Endoscopy

KW - Inflammation

KW - Leukocytes

KW - Microultrasound

KW - Small Bowel

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U2 - 10.1109/ULTSYM.2015.0304

DO - 10.1109/ULTSYM.2015.0304

M3 - Conference contribution

AN - SCOPUS:84962025413

SN - 9781479981823

BT - 2015 IEEE International Ultrasonics Symposium, IUS 2015

PB - Institute of Electrical and Electronics Engineers

Y2 - 21 October 2015 through 24 October 2015

ER -

Microultraound and small bowel inflammation: Tissue phantom studies

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this

Microultraound and small bowel inflammation: Tissue phantom studies

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this