Microultraound and small bowel inflammation: Tissue phantom studies

Benjamin F. Cox (Lead / Corresponding author), Vipin Seetohul, Holly Lay, Sandy Cochran

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)
    256 Downloads (Pure)


    Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize healthy and altered tissue in a preclinical setting as well as to explore other means of imaging pathology. Samples of small bowel were cannulated and perfused with phosphate buffered saline followed by variable dilutions of polystyrene microspheres. All samples were scanned with a purpose built step scanner employing a 47 MHz single element transducer. Results indicated that tissue high frequency ultrasound demonstrated sufficient sensitivity to detect the disruption normal histology with microsphere infusion. The combination of microultrasound and capsule endoscopy has the potential to enhance the diagnostic capabilities with improved qualitative and quantitative dimensions.

    Original languageEnglish
    Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
    PublisherInstitute of Electrical and Electronics Engineers
    ISBN (Print)9781479981823
    Publication statusPublished - 13 Nov 2015
    EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
    Duration: 21 Oct 201524 Oct 2015


    ConferenceIEEE International Ultrasonics Symposium, IUS 2015
    Country/TerritoryTaiwan, Province of China


    • Capsule Endoscopy
    • Inflammation
    • Leukocytes
    • Microultrasound
    • Small Bowel

    ASJC Scopus subject areas

    • Acoustics and Ultrasonics


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