MIDA boronate allylation-synthesis of ibuprofen

David Phillips, Glen Brodie, Sarah Memarzadeh, Gi Lum Tang, David J. France

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Abstract

MIDA boronates are among the most useful reagents for the Suzuki-Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen. This journal is

Original languageEnglish
Pages (from-to)30624-30630
Number of pages7
JournalRSC Advances
Volume10
Issue number51
DOIs
Publication statusPublished - 18 Aug 2020

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