Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focussing on carotenoids and polyphenols

Torsten Bohn (Lead / Corresponding author), Gordon J. McDougall, Amparo Alegría, Marie Alminger, Eva Arrigoni, Anna-Marja Aura, Catarina Brito, Antonio Cilla, Sedef N. El, Sibel Karakaya, Marie C. Martinez-Cuesta, Claudia N. Santos

    Research output: Contribution to journalArticlepeer-review

    198 Citations (Scopus)

    Abstract

    Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardio-vascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammatory and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose and host related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption. This article is protected by copyright. All rights reserved.

    Original languageEnglish
    Pages (from-to)1307-1323
    Number of pages17
    JournalMolecular Nutrition & Food Research
    Volume59
    Issue number7
    Early online date18 May 2015
    DOIs
    Publication statusPublished - Jul 2015

    Fingerprint

    Dive into the research topics of 'Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focussing on carotenoids and polyphenols'. Together they form a unique fingerprint.

    Cite this