Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements

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• Finished

  Regulation of DNA Interstrand Crosslink Repaid by Ubiquitin (ICLUB) (ERC Consolidator)

  Walden, H. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/09/16 → 31/08/22

  Project: Research

  • Ubiquitin 100%
  • FANCD2 73%
  • Deubiquitinating Enzyme 66%
  • Ubiquitin-specific Protease 66%
  • Deubiquitination 66%

• DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/18

  Project: Research

  • Ubiquitin Ligase 100%
  • Proteolysis 86%
  • Small Molecule 57%
  • Ubiquitin-Conjugating Enzyme 54%
  • Ternary Complex 54%

• Dissecting and Exploiting Molecular Recognition at Protein-Protein Interfaces (David Phillips Fellowship)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/07/15

  Project: Research

  • Small Molecule 100%
  • Bromodomain 90%
  • Ubiquitin-Conjugating Enzyme 78%
  • Ubiquitin Ligase 70%
  • Cullin 51%