Minimum information about a bioactive entity (MIABE)

Sandra Orchard, Bissan Al-Lazikani, Steve Bryant, Dominic Clark, Elizabeth Calder, Ian Dix, Ola Engkvist, Mark Forster, Anna Gaulton, Michael Gilson, Robert Glen, Martin Grigorov, Kim Hammond-Kosack, Lee Harland, Andrew Hopkins, Christopher Larminie, Nick Lynch, Romeena K. Mann, Peter Murray-Rust, Elena Lo PiparoChristopher Southan, Christoph Steinbeck, David Wishart, Henning Hermjakob, John Overington, Janet Thornton

    Research output: Contribution to journalReview article

    68 Citations (Scopus)

    Abstract

    Bioactive molecules such as drugs, pesticides and food additives are produced in large numbers by many commercial and academic groups around the world. Enormous quantities of data are generated on the biological properties and quality of these molecules. Access to such data - both on licensed and commercially available compounds, and also on those that fail during development - is crucial for understanding how improved molecules could be developed. For example, computational analysis of aggregated data on molecules that are investigated in drug discovery programmes has led to a greater understanding of the properties of successful drugs. However, the information required to perform these analyses is rarely published, and when it is made available it is often missing crucial data or is in a format that is inappropriate for efficient data-mining. Here, we propose a solution: the definition of reporting guidelines for bioactive entities - the Minimum Information About a Bioactive Entity (MIABE) - which has been developed by representatives of pharmaceutical companies, data resource providers and academic groups.

    Original languageEnglish
    Pages (from-to)661-669
    Number of pages9
    JournalNature Reviews Drug Discovery
    Volume10
    Issue number9
    DOIs
    Publication statusPublished - Sep 2011

    Keywords

    • BINDING-SITES
    • DRUGGABILITY
    • ONTOLOGY
    • DATABASE
    • GENOME

    Cite this

    Orchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., ... Thornton, J. (2011). Minimum information about a bioactive entity (MIABE). Nature Reviews Drug Discovery, 10(9), 661-669. https://doi.org/10.1038/nrd3503