Minireview

food for thought: regulation of synaptic function by metabolic hormones

Gemma McGregor, Yasaman Malekizadeh, Jenni Harvey (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The peripheral actions of the metabolic hormones, leptin and insulin, are well documented. However, the functions of these hormones are not restricted to the periphery because evidence is growing that both leptin and insulin can readily cross the blood-brain barrier and have widespread central actions. The hippocampus in particular expresses high levels of both insulin and leptin receptors as well as key components of their associated signaling cascades. Moreover, recent studies indicate that both hormones are potential cognitive enhancers. Indeed, it has been demonstrated that both leptin and insulin markedly influence key cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and the trafficking of glutamate receptors to and away from hippocampal synapses. The hippocampal formation is also a prime site for the neurodegenerative processes that occur during Alzheimer's disease, and impairments in either leptin or insulin function have been linked to central nervous system-driven diseases like Alzheimer's disease. Thus, the capacity of the metabolic hormones, leptin and insulin, to regulate hippocampal synaptic function has significant implications for normal brain function and also central nervous system-driven disease.

    Original languageEnglish
    Pages (from-to)3-13
    Number of pages11
    JournalMolecular Endocrinology
    Volume29
    Issue number1
    Early online date3 Dec 2014
    DOIs
    Publication statusPublished - Jan 2015

    Fingerprint

    Leptin
    Hormones
    Insulin
    Central Nervous System Diseases
    Hippocampus
    Alzheimer Disease
    Nootropic Agents
    Leptin Receptors
    Neuronal Plasticity
    Insulin Receptor
    Glutamate Receptors
    Blood-Brain Barrier
    Synapses
    Learning
    Brain

    Cite this

    McGregor, Gemma ; Malekizadeh, Yasaman ; Harvey, Jenni. / Minireview : food for thought: regulation of synaptic function by metabolic hormones. In: Molecular Endocrinology. 2015 ; Vol. 29, No. 1. pp. 3-13.
    @article{fe6c8df7dab841d7ba7bf2e1fed7df38,
    title = "Minireview: food for thought: regulation of synaptic function by metabolic hormones",
    abstract = "The peripheral actions of the metabolic hormones, leptin and insulin, are well documented. However, the functions of these hormones are not restricted to the periphery because evidence is growing that both leptin and insulin can readily cross the blood-brain barrier and have widespread central actions. The hippocampus in particular expresses high levels of both insulin and leptin receptors as well as key components of their associated signaling cascades. Moreover, recent studies indicate that both hormones are potential cognitive enhancers. Indeed, it has been demonstrated that both leptin and insulin markedly influence key cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and the trafficking of glutamate receptors to and away from hippocampal synapses. The hippocampal formation is also a prime site for the neurodegenerative processes that occur during Alzheimer's disease, and impairments in either leptin or insulin function have been linked to central nervous system-driven diseases like Alzheimer's disease. Thus, the capacity of the metabolic hormones, leptin and insulin, to regulate hippocampal synaptic function has significant implications for normal brain function and also central nervous system-driven disease.",
    author = "Gemma McGregor and Yasaman Malekizadeh and Jenni Harvey",
    year = "2015",
    month = "1",
    doi = "10.1210/me.2014-1328",
    language = "English",
    volume = "29",
    pages = "3--13",
    journal = "Molecular Endocrinology",
    issn = "0888-8809",
    publisher = "The Endocrine Society",
    number = "1",

    }

    Minireview : food for thought: regulation of synaptic function by metabolic hormones. / McGregor, Gemma; Malekizadeh, Yasaman; Harvey, Jenni (Lead / Corresponding author).

    In: Molecular Endocrinology, Vol. 29, No. 1, 01.2015, p. 3-13.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Minireview

    T2 - food for thought: regulation of synaptic function by metabolic hormones

    AU - McGregor, Gemma

    AU - Malekizadeh, Yasaman

    AU - Harvey, Jenni

    PY - 2015/1

    Y1 - 2015/1

    N2 - The peripheral actions of the metabolic hormones, leptin and insulin, are well documented. However, the functions of these hormones are not restricted to the periphery because evidence is growing that both leptin and insulin can readily cross the blood-brain barrier and have widespread central actions. The hippocampus in particular expresses high levels of both insulin and leptin receptors as well as key components of their associated signaling cascades. Moreover, recent studies indicate that both hormones are potential cognitive enhancers. Indeed, it has been demonstrated that both leptin and insulin markedly influence key cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and the trafficking of glutamate receptors to and away from hippocampal synapses. The hippocampal formation is also a prime site for the neurodegenerative processes that occur during Alzheimer's disease, and impairments in either leptin or insulin function have been linked to central nervous system-driven diseases like Alzheimer's disease. Thus, the capacity of the metabolic hormones, leptin and insulin, to regulate hippocampal synaptic function has significant implications for normal brain function and also central nervous system-driven disease.

    AB - The peripheral actions of the metabolic hormones, leptin and insulin, are well documented. However, the functions of these hormones are not restricted to the periphery because evidence is growing that both leptin and insulin can readily cross the blood-brain barrier and have widespread central actions. The hippocampus in particular expresses high levels of both insulin and leptin receptors as well as key components of their associated signaling cascades. Moreover, recent studies indicate that both hormones are potential cognitive enhancers. Indeed, it has been demonstrated that both leptin and insulin markedly influence key cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and the trafficking of glutamate receptors to and away from hippocampal synapses. The hippocampal formation is also a prime site for the neurodegenerative processes that occur during Alzheimer's disease, and impairments in either leptin or insulin function have been linked to central nervous system-driven diseases like Alzheimer's disease. Thus, the capacity of the metabolic hormones, leptin and insulin, to regulate hippocampal synaptic function has significant implications for normal brain function and also central nervous system-driven disease.

    UR - http://www.scopus.com/inward/record.url?scp=84922274009&partnerID=8YFLogxK

    U2 - 10.1210/me.2014-1328

    DO - 10.1210/me.2014-1328

    M3 - Article

    VL - 29

    SP - 3

    EP - 13

    JO - Molecular Endocrinology

    JF - Molecular Endocrinology

    SN - 0888-8809

    IS - 1

    ER -