Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55

Christopher M. Henstridge, Nariman A. B. Balenga, Julia Kargl, Clara Andradas, Andrew J. Brown, Andrew Irving, Cristina Sanchez, Maria Waldhoer

Research output: Contribution to journalReview article

97 Citations (Scopus)

Abstract

Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a candidate; however, GPR55 is phylogenetically distinct from the traditional cannabinoid receptors, and the conflicting pharmacology, signaling, and functional data have prevented its classification as a novel cannabinoid receptor. Indeed, the most consistent and potent agonist to date is the noncannabinoid lysophospholipid, lysophosphatidylinositol. Here we present new human GPR55 mRNA expression data, providing supportive evidence of GPR55 expression in a vast array of tissues and cell types. Moreover, we summarize major recent developments in GPR55 research and aim to update the reader in the rapidly expanding fields of GPR55 pharmacology, physiology, and pathology. (Molecular Endocrinology 25: 1835-1848, 2011)

Original languageEnglish
Pages (from-to)1835-1848
Number of pages14
JournalMolecular Endocrinology
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • PROTEIN-COUPLED RECEPTOR
  • L-ALPHA-LYSOPHOSPHATIDYLINOSITOL
  • CANNABINOID-LIKE RECEPTORS
  • CANCER-CELL PROLIFERATION
  • BREAST-CANCER
  • ABNORMAL-CANNABIDIOL
  • LIGAND-BINDING
  • MESENTERIC VASODILATION
  • SYNAPTIC-TRANSMISSION
  • INTERNATIONAL UNION

Cite this

Henstridge, C. M., Balenga, N. A. B., Kargl, J., Andradas, C., Brown, A. J., Irving, A., Sanchez, C., & Waldhoer, M. (2011). Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55. Molecular Endocrinology, 25(11), 1835-1848. https://doi.org/10.1210/me.2011-1197