MITI minimum information guidelines for highly multiplexed tissue images

, Denis Schapiro, Clarence Yapp, Artem Sokolov, Sheila M. Reynolds, Yu-An Chen, Damir Sudar, Yubin Xie, Jeremy Muhlich, Raquel Arias-Camison, Sarah Arena, Adam J. Taylor, Milen Nikolov, Madison Tyler, Jia-Ren Lin, Erik A. Burlingame, Young H. Chang, Samouil L. Farhi, Vésteinn Thorsson, Nithya VenkatamohanJulia L. Drewes, Dana Pe'er, David A. Gutman, Markus D. Herrmann, Nils Gehlenborg, Peter Bankhead, Joseph T. Roland, John M Herndon, Michael P Snyder, Michael Angelo, Garry Nolan, Jason R. Swedlow, Nikolaus Schultz, Daniel T. Merrick, Sarah A. Mazzili, Ethan Cerami, Scott J. Rodig, Sandro Santagata (Lead / Corresponding author), Peter K. Sorger (Lead / Corresponding author)

    Research output: Contribution to journalComment/debatepeer-review

    25 Citations (Scopus)
    64 Downloads (Pure)


    The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.
    Original languageEnglish
    Pages (from-to)262-267
    Number of pages6
    JournalNature Methods
    Issue number3
    Early online date11 Mar 2022
    Publication statusPublished - 21 Mar 2022


    • Data publication and archiving
    • Databases
    • Image processing
    • Standards

    ASJC Scopus subject areas

    • Molecular Biology
    • Biochemistry
    • Biotechnology
    • Cell Biology


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