Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

Christopher Lipina, Andrew J. Irving, Harinder S. Hundal (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced ligands called endocannabinoids. Importantly, this signalling system is known to play an important role in modulating energy balance and glucose homeostasis. For example, current evidence indicates that the ECS becomes overactive during obesity whereby its central and peripheral stimulation drives metabolic processes that mimic the metabolic syndrome. Herein, we examine the role of the ECS in modulating the function of mitochondria which play a pivotal role in maintaining cellular and systemic energy homeostasis, in large part due to their ability to tightly coordinate glucose and lipid utilisation. Because of this, mitochondrial dysfunction is often associated with peripheral insulin resistance and glucose intolerance, as well as the manifestation of excess lipid accumulation in the obese state. This review aims to highlight the different ways through which the ECS may impact upon mitochondrial abundance and/or oxidative capacity, and where possible, relate these findings to obesity-induced perturbations in metabolic function. Furthermore, we explore the potential implications of these findings in terms of the pathogenesis of metabolic disorders and how these may be used to strategically develop therapies targeting the ECS.
    Original languageEnglish
    Pages (from-to)E1-E13
    JournalAmerican Journal of Physiology, Endocrinology and Metabolism
    Volume307
    Issue number1
    Early online date6 May 2014
    DOIs
    Publication statusPublished - 1 Jul 2014

    Fingerprint

    Endocannabinoids
    Mitochondria
    Homeostasis
    Obesity
    Physiological Phenomena
    Lipids
    Glucose
    Glucose Intolerance
    Vascular Resistance
    Insulin Resistance
    Nexus
    Ligands

    Cite this

    @article{853e5dd344d9438698f29c09825d69e4,
    title = "Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?",
    abstract = "The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced ligands called endocannabinoids. Importantly, this signalling system is known to play an important role in modulating energy balance and glucose homeostasis. For example, current evidence indicates that the ECS becomes overactive during obesity whereby its central and peripheral stimulation drives metabolic processes that mimic the metabolic syndrome. Herein, we examine the role of the ECS in modulating the function of mitochondria which play a pivotal role in maintaining cellular and systemic energy homeostasis, in large part due to their ability to tightly coordinate glucose and lipid utilisation. Because of this, mitochondrial dysfunction is often associated with peripheral insulin resistance and glucose intolerance, as well as the manifestation of excess lipid accumulation in the obese state. This review aims to highlight the different ways through which the ECS may impact upon mitochondrial abundance and/or oxidative capacity, and where possible, relate these findings to obesity-induced perturbations in metabolic function. Furthermore, we explore the potential implications of these findings in terms of the pathogenesis of metabolic disorders and how these may be used to strategically develop therapies targeting the ECS.",
    author = "Christopher Lipina and Irving, {Andrew J.} and Hundal, {Harinder S.}",
    year = "2014",
    month = "7",
    day = "1",
    doi = "10.1152/ajpendo.00100.2014",
    language = "English",
    volume = "307",
    pages = "E1--E13",
    journal = "American Journal of Physiology, Endocrinology and Metabolism",
    issn = "0193-1849",
    publisher = "American Physiological Society",
    number = "1",

    }

    TY - JOUR

    T1 - Mitochondria

    T2 - a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

    AU - Lipina, Christopher

    AU - Irving, Andrew J.

    AU - Hundal, Harinder S.

    PY - 2014/7/1

    Y1 - 2014/7/1

    N2 - The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced ligands called endocannabinoids. Importantly, this signalling system is known to play an important role in modulating energy balance and glucose homeostasis. For example, current evidence indicates that the ECS becomes overactive during obesity whereby its central and peripheral stimulation drives metabolic processes that mimic the metabolic syndrome. Herein, we examine the role of the ECS in modulating the function of mitochondria which play a pivotal role in maintaining cellular and systemic energy homeostasis, in large part due to their ability to tightly coordinate glucose and lipid utilisation. Because of this, mitochondrial dysfunction is often associated with peripheral insulin resistance and glucose intolerance, as well as the manifestation of excess lipid accumulation in the obese state. This review aims to highlight the different ways through which the ECS may impact upon mitochondrial abundance and/or oxidative capacity, and where possible, relate these findings to obesity-induced perturbations in metabolic function. Furthermore, we explore the potential implications of these findings in terms of the pathogenesis of metabolic disorders and how these may be used to strategically develop therapies targeting the ECS.

    AB - The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced ligands called endocannabinoids. Importantly, this signalling system is known to play an important role in modulating energy balance and glucose homeostasis. For example, current evidence indicates that the ECS becomes overactive during obesity whereby its central and peripheral stimulation drives metabolic processes that mimic the metabolic syndrome. Herein, we examine the role of the ECS in modulating the function of mitochondria which play a pivotal role in maintaining cellular and systemic energy homeostasis, in large part due to their ability to tightly coordinate glucose and lipid utilisation. Because of this, mitochondrial dysfunction is often associated with peripheral insulin resistance and glucose intolerance, as well as the manifestation of excess lipid accumulation in the obese state. This review aims to highlight the different ways through which the ECS may impact upon mitochondrial abundance and/or oxidative capacity, and where possible, relate these findings to obesity-induced perturbations in metabolic function. Furthermore, we explore the potential implications of these findings in terms of the pathogenesis of metabolic disorders and how these may be used to strategically develop therapies targeting the ECS.

    U2 - 10.1152/ajpendo.00100.2014

    DO - 10.1152/ajpendo.00100.2014

    M3 - Article

    C2 - 24801388

    VL - 307

    SP - E1-E13

    JO - American Journal of Physiology, Endocrinology and Metabolism

    JF - American Journal of Physiology, Endocrinology and Metabolism

    SN - 0193-1849

    IS - 1

    ER -