Mitochondria and peroxisomes: partners in autophagy

Léa P Wilhelm, Ian G Ganley (Lead / Corresponding author)

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Abstract

Mitochondria, often called "the powerhouse" of the cell due to their role as the main energy supplier, regulate numerous complex processes including intracellular calcium homeostasis, reactive oxygen species (ROS) production, regulation of immune responses, and apoptosis. So, mitochondria are a fundamental metabolic hub that also control cell survival and cell death. However, they are not unique in all these functions. Indeed, peroxisomes are small cytoplasmic organelles that also ensure metabolic functions such as fatty acid oxidation and ROS production. This common relationship also extends beyond function as peroxisomes themselves can form from mitochondrial-derived precursors. Given this interconnection between mitochondria and peroxisomes involving biogenesis and function, in our recent work we determined if their turnover was also linked.

Original languageEnglish
Number of pages2
JournalAutophagy
Early online date26 Dec 2022
DOIs
Publication statusE-pub ahead of print - 26 Dec 2022

Keywords

  • autophagy
  • mitophagy
  • pexophagy
  • BNIP3L
  • NIX

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