Mitochondrial Function and Cell Size: An Allometric Relationship

Teemu P. Miettinen (Lead / Corresponding author), Mikael Björklund (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    88 Citations (Scopus)

    Abstract

    Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.

    Original languageEnglish
    Pages (from-to)393-402
    Number of pages10
    JournalTrends in Cell Biology
    Volume27
    Issue number6
    Early online date8 Mar 2017
    DOIs
    Publication statusPublished - Jun 2017

    Keywords

    • Journal article
    • Review

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