Mitochondrial Function and Cell Size: An Allometric Relationship

Teemu P. Miettinen; Mikael Björklund

doi:10.1016/j.tcb.2017.02.006

Mitochondrial Function and Cell Size: An Allometric Relationship

Teemu P. Miettinen (Lead / Corresponding author)
, Mikael Björklund (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

112 Citations (Scopus)

Abstract

Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.

Original language	English
Pages (from-to)	393-402
Number of pages	10
Journal	Trends in Cell Biology
Volume	27
Issue number	6
Early online date	8 Mar 2017
DOIs	https://doi.org/10.1016/j.tcb.2017.02.006
Publication status	Published - Jun 2017

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Journal article
Review

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title = "Mitochondrial Function and Cell Size: An Allometric Relationship",

abstract = "Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.",

keywords = "Journal article, Review",

author = "Miettinen, \{Teemu P.\} and Mikael Bj{\"o}rklund",

note = "T.P.M. is supported by the Wellcome Trust Sir Henry Postdoctoral Fellowship Invited review article.",

year = "2017",

month = jun,

doi = "10.1016/j.tcb.2017.02.006",

language = "English",

volume = "27",

pages = "393--402",

journal = "Trends in Cell Biology",

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T1 - Mitochondrial Function and Cell Size

T2 - An Allometric Relationship

AU - Miettinen, Teemu P.

AU - Björklund, Mikael

N1 - T.P.M. is supported by the Wellcome Trust Sir Henry Postdoctoral Fellowship Invited review article.

PY - 2017/6

Y1 - 2017/6

N2 - Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.

AB - Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.

KW - Journal article

KW - Review

U2 - 10.1016/j.tcb.2017.02.006

DO - 10.1016/j.tcb.2017.02.006

M3 - Review article

C2 - 28284466

SN - 0962-8924

VL - 27

SP - 393

EP - 402

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 6

ER -

Mitochondrial Function and Cell Size: An Allometric Relationship

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