Mitotic mechanics: the auroras come into view

Paul D Andrews; Elena Knatko; William J Moore; Jason R Swedlow

doi:10.1016/j.ceb.2003.10.013

Mitotic mechanics: the auroras come into view

Paul D Andrews, Elena Knatko, William J Moore, Jason R Swedlow (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

263 Citations (Scopus)

Abstract

Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

Original language	English
Pages (from-to)	672-683
Number of pages	12
Journal	Current Opinion in Cell Biology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.ceb.2003.10.013
Publication status	Published - Dec 2003

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2003.10.013

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abstract = "Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.",

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Mitotic mechanics: the auroras come into view

Abstract

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