Mitotic mechanics: the auroras come into view

Paul D Andrews, Elena Knatko, William J Moore, Jason R Swedlow (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    257 Citations (Scopus)

    Abstract

    Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

    Original languageEnglish
    Pages (from-to)672-683
    Number of pages12
    JournalCurrent Opinion in Cell Biology
    Volume15
    Issue number6
    DOIs
    Publication statusPublished - Dec 2003

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