Abstract
Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
| Original language | English |
|---|---|
| Pages (from-to) | 672-683 |
| Number of pages | 12 |
| Journal | Current Opinion in Cell Biology |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2003 |
ASJC Scopus subject areas
- Cell Biology
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