Modeling Alzheimer’s disease brains in Vitro

Christopher Henstridge; Tara Spires-Jones

doi:10.1038/s41593-018-0177-2

Modeling Alzheimer’s disease brains in Vitro

Christopher Henstridge
, Tara Spires-Jones

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.

Original language	English
Pages (from-to)	899-900
Number of pages	2
Journal	Nature Neuroscience
Volume	21
DOIs	https://doi.org/10.1038/s41593-018-0177-2
Publication status	Published - 27 Jun 2018

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SDG 3 Good Health and Well-being

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10.1038/s41593-018-0177-2

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AB - Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.

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Modeling Alzheimer’s disease brains in Vitro

Abstract

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