Modelling oscillator synchronisation during vertebrate axis segmentation

Philip J. Murray, Philip K. Maini (Lead / Corresponding author), Ruth E. Baker

Research output: Contribution to journalArticle

Abstract

The somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling mechanisms. Here we consider a population of phase-coupled oscillators and investigate how biologically motivated perturbations to the entrained state can perturb synchrony within the population. We find that the ratio of mitosis length to clock period can influence levels of desynchronisation. Moreover, we observe that random cell movement, and hence change of local neighbourhoods, increases synchronisation.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalSpringer Proceedings in Mathematics
Volume15
Issue number1
Early online date5 Aug 2012
DOIs
Publication statusPublished - 22 Apr 2013

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