Modelling the microscopic mechanisms of sonoporation

J. M. Burns, P. A. Prentice, A. Cuschieri, P. A. Campbell (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Exposure of biological tissues to ultrasound waves above a threshold pressure amplitude can lead to permeabilization of the cell membrane and the unregulated uptake of exogenous species from the locale. This process is known as sonoporation. The approach appears to have significant potential for the non-invasive treatment of diseased and dysfunctional tissues. Interestingly, the extent of molecular uptake is noticeably enhanced when microscopic bubbles, usually in the form of commercial ultrasound contrast agents (UCA) are present during ultrasound exposure [insonation]. The physical mechanism leading to enhanced permeabilization had, until recently, remained elusive. It has emerged that the microbubbles effectively act as pre-nucleated cavitation centres and that their proximity to hydrodynamic constraints [nominally tissue planes] leads naturally to asymmetric collapse and the formation of microjets. For the purposes of the present paper, we show by comparison with in-house generated observations, that a computational model based on boundary element methods goes some way to simulating many of the salient aspects of cavitating microbubbles near boundaries, including microjetting.

Original languageEnglish
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
PublisherCRC Press
Pages333-336
Number of pages4
Volume2
Edition1
ISBN (Print)0976798573, 9780976798576
Publication statusPublished - 11 Jun 2007
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: 7 May 200611 May 2006

Conference

Conference2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period7/05/0611/05/06

Keywords

  • Boundary element method
  • Boundary integrals
  • Microjetting
  • Rayleigh-Plesset equation
  • Sonoporation

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