Modelling vascularity in breast cancer and surrounding stroma using diffusion MRI and intravoxel incoherent motion

Colleen Bailey (Lead / Corresponding author), Sarah Vinnicombe, Eleftheria Panagiotaki, Shelley A. Waugh, John H. Hipwell, Daniel C. Alexander, Kathryn Kitching, Patsy Whelehan, Sarah E. Pinder, Andrew Evans, David J. Hawkes

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Contrast-enhanced magnetic resonance imaging (MRI) has shown variation in the stroma with distance from the tumor and this correlates with histological microvessel density. To date, however, conventional diffusion MRI has demonstrated limited sensitivity to these changes. This study modelled the diffusion signal by intravoxel incoherent motion (IVIM) to obtain parameters related to the vasculature and tissue diffusion. This revealed a small vascular contribution to the signal in tumor and peri-tumoral stroma within 8 mm. Monoexponential fitting performed worse than the IVIM model in tumor and stroma within 8 mm, but was sufficient in more distal stromal regions where lower microvessel density is expected. Modelling diffusion MRI by IVIM provided a measure of vascularity that may complement information from DCE-MRI and yielded additional information about diffusion in the extravascular tissue.

    Original languageEnglish
    Title of host publicationBreast Imaging
    Subtitle of host publication12th International Workshop, IWDM 2014, Gifu City, Japan, June 29 – July 2, 2014. Proceedings
    EditorsHiroshi Fujita, Takeshi Hara, Chisako Muramatsu
    PublisherSpringer International Publishing
    Number of pages7
    ISBN (Electronic)9783319078878
    ISBN (Print)9783319078861
    Publication statusPublished - 2014
    Event12th International Workshop on Breast Imaging - Juroku Plaza, Gifu City, Japan
    Duration: 29 Jun 20142 Jul 2014

    Publication series

    NameLecture notes in computer science
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349


    Workshop12th International Workshop on Breast Imaging
    Abbreviated titleIWDM 2014
    CityGifu City
    Internet address


    • breast cancer
    • diffusion MRI
    • IVIM
    • modelling
    • stroma
    • vascularity

    ASJC Scopus subject areas

    • General Computer Science
    • Theoretical Computer Science


    Dive into the research topics of 'Modelling vascularity in breast cancer and surrounding stroma using diffusion MRI and intravoxel incoherent motion'. Together they form a unique fingerprint.

    Cite this