Modulation of an inhibitory jaw reflex by remote noxious stimulation: effects of spatial conditioning factors

Andrew G. Mason, James P. Newton, Samuel W. Cadden

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    In humans, inhibitory jaw reflexes can be depressed by painful stimulation of remote parts of the body. The underlying mechanisms may involve diffuse noxious inhibitory controls (DNIC). Animal experiments have shown that the neurons which may mediate DNIC show spatial encoding (i.e. their responses vary in relation to the size of the body area being stimulated). The aim of this study was to investigate whether the modulation of an inhibitory jaw reflex shows similar spatial dependency. Electromyographic recordings were made in 9 subjects, from a masseter muscle that was activated to a level equivalent to 10% of that obtained during a maximum voluntary contraction. Reflex inhibitions were evoked by electrical stimuli to the upper lip, either alone (controls) or during the application of conditioning stimuli (47°C water) to the fingers, the hand, the half forearm or the whole forearm. Conditioning stimuli applied to the larger but not to the smaller areas resulted in significant modulations of the reflex. There was a significant correlation between stimulus area and reflex magnitude. These results demonstrate a spatial dependency for the modulation of an inhibitory jaw reflex by painful stimuli – a further parallel with DNIC as studied on single neurons in animals.
    Original languageEnglish
    Pages (from-to)371-377
    Number of pages7
    JournalEuropean Journal of Oral Sciences
    Volume115
    Issue number5
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Jaw
    Reflex
    Diffuse Noxious Inhibitory Control
    Spatial Analysis
    Forearm
    Neurons
    Masseter Muscle
    Body Size
    Lip
    Human Body
    Fingers
    Conditioning (Psychology)
    Hand
    Water

    Keywords

    • Diffuse noxious inhibitory controls (DNIC)
    • Jaw
    • Modulation
    • Pain
    • Reflex

    Cite this

    @article{1cac39ce8d5e42878e7a734ee9a7b6ce,
    title = "Modulation of an inhibitory jaw reflex by remote noxious stimulation: effects of spatial conditioning factors",
    abstract = "In humans, inhibitory jaw reflexes can be depressed by painful stimulation of remote parts of the body. The underlying mechanisms may involve diffuse noxious inhibitory controls (DNIC). Animal experiments have shown that the neurons which may mediate DNIC show spatial encoding (i.e. their responses vary in relation to the size of the body area being stimulated). The aim of this study was to investigate whether the modulation of an inhibitory jaw reflex shows similar spatial dependency. Electromyographic recordings were made in 9 subjects, from a masseter muscle that was activated to a level equivalent to 10{\%} of that obtained during a maximum voluntary contraction. Reflex inhibitions were evoked by electrical stimuli to the upper lip, either alone (controls) or during the application of conditioning stimuli (47°C water) to the fingers, the hand, the half forearm or the whole forearm. Conditioning stimuli applied to the larger but not to the smaller areas resulted in significant modulations of the reflex. There was a significant correlation between stimulus area and reflex magnitude. These results demonstrate a spatial dependency for the modulation of an inhibitory jaw reflex by painful stimuli – a further parallel with DNIC as studied on single neurons in animals.",
    keywords = "Diffuse noxious inhibitory controls (DNIC), Jaw, Modulation, Pain, Reflex",
    author = "Mason, {Andrew G.} and Newton, {James P.} and Cadden, {Samuel W.}",
    note = "dc.publisher: John Wiley & Sons Demonstrates that the pattern of modulation of a jaw reflex in man shows similar spatial characteristics as the response properties of neurones that mediate the phenomenon {"}Diffuse Noxious Inhibitory Controls{"} (DNIC) in experimental animals. Thus providing further evidence that DNIC pathways may be involved in the modulation of jaw reflexes.",
    year = "2007",
    doi = "10.1111/j.1600-0722.2007.00470.x",
    language = "English",
    volume = "115",
    pages = "371--377",
    journal = "European Journal of Oral Sciences",
    issn = "0909-8836",
    publisher = "Wiley",
    number = "5",

    }

    Modulation of an inhibitory jaw reflex by remote noxious stimulation: effects of spatial conditioning factors. / Mason, Andrew G.; Newton, James P.; Cadden, Samuel W.

    In: European Journal of Oral Sciences, Vol. 115, No. 5, 2007, p. 371-377.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Modulation of an inhibitory jaw reflex by remote noxious stimulation: effects of spatial conditioning factors

    AU - Mason, Andrew G.

    AU - Newton, James P.

    AU - Cadden, Samuel W.

    N1 - dc.publisher: John Wiley & Sons Demonstrates that the pattern of modulation of a jaw reflex in man shows similar spatial characteristics as the response properties of neurones that mediate the phenomenon "Diffuse Noxious Inhibitory Controls" (DNIC) in experimental animals. Thus providing further evidence that DNIC pathways may be involved in the modulation of jaw reflexes.

    PY - 2007

    Y1 - 2007

    N2 - In humans, inhibitory jaw reflexes can be depressed by painful stimulation of remote parts of the body. The underlying mechanisms may involve diffuse noxious inhibitory controls (DNIC). Animal experiments have shown that the neurons which may mediate DNIC show spatial encoding (i.e. their responses vary in relation to the size of the body area being stimulated). The aim of this study was to investigate whether the modulation of an inhibitory jaw reflex shows similar spatial dependency. Electromyographic recordings were made in 9 subjects, from a masseter muscle that was activated to a level equivalent to 10% of that obtained during a maximum voluntary contraction. Reflex inhibitions were evoked by electrical stimuli to the upper lip, either alone (controls) or during the application of conditioning stimuli (47°C water) to the fingers, the hand, the half forearm or the whole forearm. Conditioning stimuli applied to the larger but not to the smaller areas resulted in significant modulations of the reflex. There was a significant correlation between stimulus area and reflex magnitude. These results demonstrate a spatial dependency for the modulation of an inhibitory jaw reflex by painful stimuli – a further parallel with DNIC as studied on single neurons in animals.

    AB - In humans, inhibitory jaw reflexes can be depressed by painful stimulation of remote parts of the body. The underlying mechanisms may involve diffuse noxious inhibitory controls (DNIC). Animal experiments have shown that the neurons which may mediate DNIC show spatial encoding (i.e. their responses vary in relation to the size of the body area being stimulated). The aim of this study was to investigate whether the modulation of an inhibitory jaw reflex shows similar spatial dependency. Electromyographic recordings were made in 9 subjects, from a masseter muscle that was activated to a level equivalent to 10% of that obtained during a maximum voluntary contraction. Reflex inhibitions were evoked by electrical stimuli to the upper lip, either alone (controls) or during the application of conditioning stimuli (47°C water) to the fingers, the hand, the half forearm or the whole forearm. Conditioning stimuli applied to the larger but not to the smaller areas resulted in significant modulations of the reflex. There was a significant correlation between stimulus area and reflex magnitude. These results demonstrate a spatial dependency for the modulation of an inhibitory jaw reflex by painful stimuli – a further parallel with DNIC as studied on single neurons in animals.

    KW - Diffuse noxious inhibitory controls (DNIC)

    KW - Jaw

    KW - Modulation

    KW - Pain

    KW - Reflex

    U2 - 10.1111/j.1600-0722.2007.00470.x

    DO - 10.1111/j.1600-0722.2007.00470.x

    M3 - Article

    VL - 115

    SP - 371

    EP - 377

    JO - European Journal of Oral Sciences

    JF - European Journal of Oral Sciences

    SN - 0909-8836

    IS - 5

    ER -