Modulation of cellular redox homeostasis by the endocannabinoid system

Christopher Lipina, Harinder S. Hundal (Lead / Corresponding author)

Research output: Contribution to journalArticle

20 Citations (Scopus)
92 Downloads (Pure)

Abstract

The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signaling systems which participate in the modulation of diverse cellular functions. Importantly, growing evidence suggests that cross-talk between these two prominent signaling systems acts to modulate functionality of the ECS as well as redox homeostasis in different cell types. Herein, we review and discuss evidence pertaining to ECS induced regulation of ROS generating and scavenging mechanisms, as well as highlighting emerging work that supports redox modulation of ECS function. Functionally, the studies outlined reveal that interactions between the ECS and ROS signaling systems can be both stimulatory and inhibitory in nature, depending on cell stimulus, the source of ROS species, and cell context. Importantly, such cross-talk may act to maintain cell function, whereas abnormalities in either system may propagate and undermine the stability of both systems, thereby contributing to various pathologies associated with their dysregulation.
Original languageEnglish
Article number150276
Pages (from-to)1-10
Number of pages10
JournalOpen Biology
Volume6
Issue number4
DOIs
Publication statusPublished - 27 Apr 2016

Fingerprint

Endocannabinoids
Oxidation-Reduction
Homeostasis
Modulation
Reactive Oxygen Species
Cell signaling
Scavenging
Pathology

Keywords

  • endocannabinoid system
  • reactive oxygen species
  • antioxidant
  • redox homeostasis
  • oxiative stress
  • cannabinoid receptor

Cite this

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title = "Modulation of cellular redox homeostasis by the endocannabinoid system",
abstract = "The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signaling systems which participate in the modulation of diverse cellular functions. Importantly, growing evidence suggests that cross-talk between these two prominent signaling systems acts to modulate functionality of the ECS as well as redox homeostasis in different cell types. Herein, we review and discuss evidence pertaining to ECS induced regulation of ROS generating and scavenging mechanisms, as well as highlighting emerging work that supports redox modulation of ECS function. Functionally, the studies outlined reveal that interactions between the ECS and ROS signaling systems can be both stimulatory and inhibitory in nature, depending on cell stimulus, the source of ROS species, and cell context. Importantly, such cross-talk may act to maintain cell function, whereas abnormalities in either system may propagate and undermine the stability of both systems, thereby contributing to various pathologies associated with their dysregulation.",
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Modulation of cellular redox homeostasis by the endocannabinoid system. / Lipina, Christopher; Hundal, Harinder S. (Lead / Corresponding author).

In: Open Biology, Vol. 6, No. 4, 150276, 27.04.2016, p. 1-10.

Research output: Contribution to journalArticle

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T1 - Modulation of cellular redox homeostasis by the endocannabinoid system

AU - Lipina, Christopher

AU - Hundal, Harinder S.

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AB - The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signaling systems which participate in the modulation of diverse cellular functions. Importantly, growing evidence suggests that cross-talk between these two prominent signaling systems acts to modulate functionality of the ECS as well as redox homeostasis in different cell types. Herein, we review and discuss evidence pertaining to ECS induced regulation of ROS generating and scavenging mechanisms, as well as highlighting emerging work that supports redox modulation of ECS function. Functionally, the studies outlined reveal that interactions between the ECS and ROS signaling systems can be both stimulatory and inhibitory in nature, depending on cell stimulus, the source of ROS species, and cell context. Importantly, such cross-talk may act to maintain cell function, whereas abnormalities in either system may propagate and undermine the stability of both systems, thereby contributing to various pathologies associated with their dysregulation.

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KW - oxiative stress

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