Modulation of cellular redox homeostasis by the endocannabinoid system

Christopher Lipina, Harinder S. Hundal (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)
194 Downloads (Pure)


The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signaling systems which participate in the modulation of diverse cellular functions. Importantly, growing evidence suggests that cross-talk between these two prominent signaling systems acts to modulate functionality of the ECS as well as redox homeostasis in different cell types. Herein, we review and discuss evidence pertaining to ECS induced regulation of ROS generating and scavenging mechanisms, as well as highlighting emerging work that supports redox modulation of ECS function. Functionally, the studies outlined reveal that interactions between the ECS and ROS signaling systems can be both stimulatory and inhibitory in nature, depending on cell stimulus, the source of ROS species, and cell context. Importantly, such cross-talk may act to maintain cell function, whereas abnormalities in either system may propagate and undermine the stability of both systems, thereby contributing to various pathologies associated with their dysregulation.
Original languageEnglish
Article number150276
Pages (from-to)1-10
Number of pages10
JournalOpen Biology
Issue number4
Publication statusPublished - 27 Apr 2016


  • endocannabinoid system
  • reactive oxygen species
  • antioxidant
  • redox homeostasis
  • oxiative stress
  • cannabinoid receptor


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