Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Rick M. Maizels; Hermelijn H. Smits; Henry J. McSorley

doi:10.1016/j.immuni.2018.10.016

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Rick M. Maizels, Hermelijn H. Smits, Henry J. McSorley

Cell Signalling and Immunology

Research output: Contribution to journal › Review article › peer-review

257 Citations (Scopus)

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Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery. Parasitic helminths modulate the immune system, preventing immune-mediated ejection and suppressing immune-mediated diseases. In this review, Maizels and colleagues describe the secreted molecules by which parasites achieve this and the methods by which these molecules have evolved.

Original language	English
Pages (from-to)	801-818
Number of pages	18
Journal	Immunity
Volume	49
Issue number	5
Early online date	20 Nov 2018
DOIs	https://doi.org/10.1016/j.immuni.2018.10.016
Publication status	Published - 20 Nov 2018

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery. Parasitic helminths modulate the immune system, preventing immune-mediated ejection and suppressing immune-mediated diseases. In this review, Maizels and colleagues describe the secreted molecules by which parasites achieve this and the methods by which these molecules have evolved.",

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AB - Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery. Parasitic helminths modulate the immune system, preventing immune-mediated ejection and suppressing immune-mediated diseases. In this review, Maizels and colleagues describe the secreted molecules by which parasites achieve this and the methods by which these molecules have evolved.

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Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Abstract

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UN SDGs

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