Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

Alejandra Catenaccio, Maica Llavero Hurtado, Paula Diaz, Douglas J. Lamont, Thomas M. Wishart, Felipe A. Court (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
188 Downloads (Pure)

Abstract

Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.

Original languageEnglish
Article numbere3166
Pages (from-to)1-14
Number of pages14
JournalCell Death and Disease
Volume8
Issue number11
DOIs
Publication statusPublished - 9 Nov 2017

Keywords

  • Journal article

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