Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

Alejandra Catenaccio, Maica Llavero Hurtado, Paula Diaz, Douglas J. Lamont, Thomas M. Wishart, Felipe A. Court (Lead / Corresponding author)

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Abstract

Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.

Original languageEnglish
Article numbere3166
Pages (from-to)1-14
Number of pages14
JournalCell Death and Disease
Volume8
Issue number11
DOIs
Publication statusPublished - 9 Nov 2017

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Wallerian Degeneration
Neuroglia
Axons
Cytokinesis
Computer Simulation
Proteomics
Cluster Analysis
Regeneration

Keywords

  • Journal article

Cite this

Catenaccio, A., Llavero Hurtado, M., Diaz, P., Lamont, D. J., Wishart, T. M., & Court, F. A. (2017). Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death and Disease, 8(11), 1-14. [e3166]. https://doi.org/10.1038/cddis.2017.489
Catenaccio, Alejandra ; Llavero Hurtado, Maica ; Diaz, Paula ; Lamont, Douglas J. ; Wishart, Thomas M. ; Court, Felipe A. / Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. In: Cell Death and Disease. 2017 ; Vol. 8, No. 11. pp. 1-14.
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Catenaccio, A, Llavero Hurtado, M, Diaz, P, Lamont, DJ, Wishart, TM & Court, FA 2017, 'Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration', Cell Death and Disease, vol. 8, no. 11, e3166, pp. 1-14. https://doi.org/10.1038/cddis.2017.489

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. / Catenaccio, Alejandra; Llavero Hurtado, Maica; Diaz, Paula; Lamont, Douglas J.; Wishart, Thomas M.; Court, Felipe A. (Lead / Corresponding author).

In: Cell Death and Disease, Vol. 8, No. 11, e3166, 09.11.2017, p. 1-14.

Research output: Contribution to journalArticle

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AU - Court, Felipe A.

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Catenaccio A, Llavero Hurtado M, Diaz P, Lamont DJ, Wishart TM, Court FA. Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death and Disease. 2017 Nov 9;8(11):1-14. e3166. https://doi.org/10.1038/cddis.2017.489