Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

Alejandra Catenaccio, Maica Llavero Hurtado, Paula Diaz, Douglas J. Lamont, Thomas M. Wishart, Felipe A. Court (Lead / Corresponding author)

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Abstract

Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.

Original languageEnglish
Article numbere3166
Pages (from-to)1-14
Number of pages14
JournalCell Death and Disease
Volume8
Issue number11
DOIs
Publication statusPublished - 9 Nov 2017

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Keywords

  • Journal article

Cite this

Catenaccio, A., Llavero Hurtado, M., Diaz, P., Lamont, D. J., Wishart, T. M., & Court, F. A. (2017). Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death and Disease, 8(11), 1-14. [e3166]. https://doi.org/10.1038/cddis.2017.489