Molecular analysis of the coiled body

K. Bohmann, J. Ferreira, N. Santama, K. Weis, A. I. Lamond

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


There is increasing interest in studying how specific metabolic activities within the nucleus are organised into functional domains. The best known example is the nucleolus where rRNA genes are transcribed and rRNA processed and assembled into ribosomal subunits. Other subnuclear domains have been known for many years through morphological studies but are only recently being analysed at the molecular level. Here we focus on an evolutionarily conserved nuclear domain, called the coiled body, which contains splicing snRNPs. We review recent literature on the coiled body and discuss a possible model for its biological function.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalJournal of Cell Science
Issue numberSUPPL. 19
Publication statusPublished - 1 Jan 1995


  • Coiled body
  • Nucleus
  • p80 coilin
  • snRNP


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