Projects per year
Abstract
Research over the past decade has revealed how NF-?B essential modulator (NEMO; also known as IKK?) regulates the IKKa-IKKß signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.
Original language | English |
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Pages (from-to) | 673-685 |
Number of pages | 13 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 14 |
Early online date | 29 Aug 2013 |
DOIs | |
Publication status | Published - 2013 |
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Dive into the research topics of 'Molecular control of the NEMO family of ubiquitin-binding proteins'. Together they form a unique fingerprint.Projects
- 2 Finished
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Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)
Cohen, P. (Investigator)
1/04/13 → 31/03/18
Project: Research
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Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)
Cohen, P. (Investigator)
1/04/13 → 31/03/18
Project: Research