Molecular control of the NEMO family of ubiquitin-binding proteins

Kristopher Clark, Sambit Nanda, Philip Cohen

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    Research over the past decade has revealed how NF-?B essential modulator (NEMO; also known as IKK?) regulates the IKKa-IKKß signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.
    Original languageEnglish
    Pages (from-to)673-685
    Number of pages13
    JournalNature Reviews Molecular Cell Biology
    Volume14
    Early online date29 Aug 2013
    DOIs
    Publication statusPublished - 2013

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