Molecular genetics of the human cytochrome P450-dependent monooxygenases

C R Wolf; C A D Smith; G Smith; A C Gough; S Bryant; N K Spurr; D J Harrison

doi:10.1620/tjem.168.73

Molecular genetics of the human cytochrome P450-dependent monooxygenases

C R Wolf, C A D Smith, G Smith, A C Gough, S Bryant, N K Spurr, D J Harrison

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no cancer type were poor metabolizers underrepresented, indeed in several cancers the mutant allele frequency was increased. A model using human tumours grown as xenografts is described that should help elucidate the factors which regulate P450 levels in man.

Original language	English
Pages (from-to)	73-81
Number of pages	9
Journal	The Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.73
Publication status	Published - 1992

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10.1620/tjem.168.73

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AU - Smith, C A D

AU - Smith, G

AU - Gough, A C

AU - Bryant, S

AU - Spurr, N K

AU - Harrison, D J

PY - 1992

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AB - In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no cancer type were poor metabolizers underrepresented, indeed in several cancers the mutant allele frequency was increased. A model using human tumours grown as xenografts is described that should help elucidate the factors which regulate P450 levels in man.

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DO - 10.1620/tjem.168.73

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JO - The Tohoku Journal of Experimental Medicine

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ER -

Molecular genetics of the human cytochrome P450-dependent monooxygenases

Abstract

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