Molecular genetics of the human cytochrome P450-dependent monooxygenases

C R Wolf, C A D Smith, G Smith, A C Gough, S Bryant, N K Spurr, D J Harrison

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no cancer type were poor metabolizers underrepresented, indeed in several cancers the mutant allele frequency was increased. A model using human tumours grown as xenografts is described that should help elucidate the factors which regulate P450 levels in man.
    Original languageEnglish
    Pages (from-to)73-81
    Number of pages9
    JournalThe Tohoku Journal of Experimental Medicine
    Volume168
    Issue number2
    DOIs
    Publication statusPublished - 1992

    Fingerprint

    Cytochrome P-450 CYP2D6
    Mixed Function Oxygenases
    Heterografts
    Cytochrome P-450 Enzyme System
    Isoenzymes
    Tumors
    Molecular Biology
    Assays
    Genes
    Defects
    DNA
    Neoplasms
    Gene Frequency
    Genetics

    Cite this

    Wolf, C R ; Smith, C A D ; Smith, G ; Gough, A C ; Bryant, S ; Spurr, N K ; Harrison, D J. / Molecular genetics of the human cytochrome P450-dependent monooxygenases. In: The Tohoku Journal of Experimental Medicine. 1992 ; Vol. 168, No. 2. pp. 73-81.
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    Molecular genetics of the human cytochrome P450-dependent monooxygenases. / Wolf, C R; Smith, C A D; Smith, G; Gough, A C; Bryant, S; Spurr, N K; Harrison, D J.

    In: The Tohoku Journal of Experimental Medicine, Vol. 168, No. 2, 1992, p. 73-81.

    Research output: Contribution to journalArticle

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    AU - Spurr, N K

    AU - Harrison, D J

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