Molecular interactions of the mitochondrial Tim12 translocase subunit

Catherine Baud; Carine De Marcos-Lousa; Kostas Tokatlidis

doi:10.2174/092986607780990019

Molecular interactions of the mitochondrial Tim12 translocase subunit

Catherine Baud, Carine De Marcos-Lousa, Kostas Tokatlidis

Drug Discovery Unit

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.

Original language	English
Pages (from-to)	597-600
Number of pages	4
Journal	Protein and Peptide Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.2174/092986607780990019
Publication status	Published - Jun 2007

Keywords

Chaperones
Mitochondria
Protein assembly
Small Tims

ASJC Scopus subject areas

Structural Biology
Biochemistry

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10.2174/092986607780990019

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title = "Molecular interactions of the mitochondrial Tim12 translocase subunit",

abstract = "The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.",

keywords = "Chaperones, Mitochondria, Protein assembly, Small Tims",

author = "Catherine Baud and {De Marcos-Lousa}, Carine and Kostas Tokatlidis",

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T1 - Molecular interactions of the mitochondrial Tim12 translocase subunit

AU - Baud, Catherine

AU - De Marcos-Lousa, Carine

AU - Tokatlidis, Kostas

PY - 2007/6

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N2 - The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.

AB - The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.

KW - Chaperones

KW - Mitochondria

KW - Protein assembly

KW - Small Tims

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AN - SCOPUS:34447291828

SN - 0929-8665

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EP - 600

JO - Protein and Peptide Letters

JF - Protein and Peptide Letters

IS - 6

ER -

Molecular interactions of the mitochondrial Tim12 translocase subunit

Abstract

Keywords

ASJC Scopus subject areas

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