Molecular mechanisms of COPII vesicle formation

Marcus C.S. Lee; Elizabeth A. Miller

doi:10.1016/j.semcdb.2007.06.007

Molecular mechanisms of COPII vesicle formation

Marcus C.S. Lee, Elizabeth A. Miller (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Review article › peer-review

74 Citations (Scopus)

Abstract

The first step in protein secretion from eukaryotic cells is mediated by COPII vesicles, known for the cytoplasmic coat proteins that are the minimal machinery required to generate these small transport carriers. The five COPII coat components coordinate to create a vesicle by locally generating membrane curvature and populating the incipient bud with the appropriate cargo. This review describes the molecular details of how the COPII coat sculpts vesicles from the endoplasmic reticulum and highlights some unresolved questions regarding the regulation of this process in the complex environment of the eukaryotic cell.

Original language	English
Pages (from-to)	424-434
Number of pages	11
Journal	Seminars in Cell and Developmental Biology
Volume	18
Issue number	4
Early online date	7 Jul 2007
DOIs	https://doi.org/10.1016/j.semcdb.2007.06.007
Publication status	Published - Aug 2007

Keywords

Cargo capture
COPII
Endoplasmic reticulum
Transport vesicle

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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AB - The first step in protein secretion from eukaryotic cells is mediated by COPII vesicles, known for the cytoplasmic coat proteins that are the minimal machinery required to generate these small transport carriers. The five COPII coat components coordinate to create a vesicle by locally generating membrane curvature and populating the incipient bud with the appropriate cargo. This review describes the molecular details of how the COPII coat sculpts vesicles from the endoplasmic reticulum and highlights some unresolved questions regarding the regulation of this process in the complex environment of the eukaryotic cell.

KW - Cargo capture

KW - COPII

KW - Endoplasmic reticulum

KW - Transport vesicle

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Molecular mechanisms of COPII vesicle formation

Abstract

Keywords

ASJC Scopus subject areas

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