Molecular mechanisms of COPII vesicle formation

Marcus C.S. Lee, Elizabeth A. Miller (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)


The first step in protein secretion from eukaryotic cells is mediated by COPII vesicles, known for the cytoplasmic coat proteins that are the minimal machinery required to generate these small transport carriers. The five COPII coat components coordinate to create a vesicle by locally generating membrane curvature and populating the incipient bud with the appropriate cargo. This review describes the molecular details of how the COPII coat sculpts vesicles from the endoplasmic reticulum and highlights some unresolved questions regarding the regulation of this process in the complex environment of the eukaryotic cell.

Original languageEnglish
Pages (from-to)424-434
Number of pages11
JournalSeminars in Cell and Developmental Biology
Issue number4
Early online date7 Jul 2007
Publication statusPublished - Aug 2007


  • Cargo capture
  • Endoplasmic reticulum
  • Transport vesicle

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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