Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

David Horn, Richard McCulloch

    Research output: Contribution to journalReview article

    88 Citations (Scopus)

    Abstract

    African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The 'pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early postgenomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation.

    Original languageEnglish
    Pages (from-to)700-705
    Number of pages6
    JournalCurrent Opinion in Microbiology
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - Dec 2010

    Keywords

    • DISTINCT ROLES
    • REPAIR
    • GENE-EXPRESSION
    • HOMOLOGOUS RECOMBINATION
    • DNA
    • TELOMERES
    • POLYMERASE I
    • BREAK-INDUCED REPLICATION
    • YEAST
    • BRUCEI

    Cite this

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    title = "Molecular mechanisms underlying the control of antigenic variation in African trypanosomes",
    abstract = "African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The 'pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early postgenomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation.",
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    author = "David Horn and Richard McCulloch",
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    Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. / Horn, David; McCulloch, Richard.

    In: Current Opinion in Microbiology, Vol. 13, No. 6, 12.2010, p. 700-705.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

    AU - Horn, David

    AU - McCulloch, Richard

    PY - 2010/12

    Y1 - 2010/12

    N2 - African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The 'pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early postgenomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation.

    AB - African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The 'pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early postgenomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation.

    KW - DISTINCT ROLES

    KW - REPAIR

    KW - GENE-EXPRESSION

    KW - HOMOLOGOUS RECOMBINATION

    KW - DNA

    KW - TELOMERES

    KW - POLYMERASE I

    KW - BREAK-INDUCED REPLICATION

    KW - YEAST

    KW - BRUCEI

    U2 - 10.1016/j.mib.2010.08.009

    DO - 10.1016/j.mib.2010.08.009

    M3 - Review article

    VL - 13

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    EP - 705

    JO - Current Opinion in Microbiology

    JF - Current Opinion in Microbiology

    SN - 1369-5274

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