Monkeypox encephalitis with transverse myelitis in a female patient

TY - JOUR

T1 - Monkeypox encephalitis with transverse myelitis in a female patient

AU - Cole, Joby

AU - Choudry, Saher

AU - Kular, Saminderjit

AU - Payne, Thomas

AU - Akili, Suha

AU - Callaby, Helen

AU - Gordon, N. Claire

AU - Ankcorn, Michael

AU - Martin, Andrew

AU - Hobson, Esther

AU - Tunbridge, Anne J.

N1 - Publisher Copyright: © 2022 Elsevier Ltd. All rights reserved.

PY - 2023/3

Y1 - 2023/3

N2 - The 2022 monkeypox outbreak has affected 110 countries worldwide, outside of classic endemic areas (ie, west Africa and central Africa). On July 23, 2022, the outbreak was classified by WHO as a public health emergency of international concern. Clinical presentation varies from mild to life-changing symptoms; neurological complications are relatively uncommon and there are few therapeutic interventions for monkeypox disease. In this Grand Round, we present a case of monkeypox with encephalitis complicated by transverse myelitis in a previously healthy woman aged 35 years who made an almost complete recovery from her neurological symptoms after treatment with tecovirimat, cidofovir, steroids, and plasma exchange. We describe neurological complications associated with orthopoxvirus infections and laboratory diagnosis, the radiological features in this case, and discuss treatment options.

AB - The 2022 monkeypox outbreak has affected 110 countries worldwide, outside of classic endemic areas (ie, west Africa and central Africa). On July 23, 2022, the outbreak was classified by WHO as a public health emergency of international concern. Clinical presentation varies from mild to life-changing symptoms; neurological complications are relatively uncommon and there are few therapeutic interventions for monkeypox disease. In this Grand Round, we present a case of monkeypox with encephalitis complicated by transverse myelitis in a previously healthy woman aged 35 years who made an almost complete recovery from her neurological symptoms after treatment with tecovirimat, cidofovir, steroids, and plasma exchange. We describe neurological complications associated with orthopoxvirus infections and laboratory diagnosis, the radiological features in this case, and discuss treatment options.

UR - https://www.scopus.com/pages/publications/85143285576

U2 - 10.1016/S1473-3099(22)00741-1

DO - 10.1016/S1473-3099(22)00741-1

M3 - Review article

C2 - 36470282

AN - SCOPUS:85143285576

SN - 1473-3099

VL - 23

SP - e115-e120

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

IS - 3

ER -