Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation

Man K. Xu, Darya Gaysina, Roula Tsonaka, Alexandre J. S. Morin, Tim J. Croudace, Jennifer H. Barnett, Jeanine Houwing-Duistermaat, Marcus Richards, Peter B. Jones, LHA Genetics Group

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Abstract

Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1160 male and 1180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β=‐0.167; CI: ‐0.289, ‐0.045; p=0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β=0.197; CI: 0.067, 0.328; p= 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modelling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.
Original languageEnglish
Article number1736
Pages (from-to)1-13
Number of pages13
JournalFrontiers in Psychology
Volume8
DOIs
Publication statusPublished - 11 Oct 2017

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Monoamine Oxidase
Personality
Phenotype
Genes
Molecular Biology
Health Surveys
Psychometrics
Single Nucleotide Polymorphism
Parturition
Psychology
Extraversion (Psychology)
Neuroticism

Keywords

  • latent variable
  • MAOA
  • personality
  • development
  • adolescents

Cite this

Xu, Man K. ; Gaysina, Darya ; Tsonaka, Roula ; Morin, Alexandre J. S. ; Croudace, Tim J. ; Barnett, Jennifer H. ; Houwing-Duistermaat, Jeanine ; Richards, Marcus ; Jones, Peter B. ; LHA Genetics Group. / Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood : A Latent Variable Investigation. In: Frontiers in Psychology. 2017 ; Vol. 8. pp. 1-13.
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abstract = "Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1160 male and 1180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β=‐0.167; CI: ‐0.289, ‐0.045; p=0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β=0.197; CI: 0.067, 0.328; p= 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modelling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.",
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note = "This work was supported by the Wellcome Trust grant (MKX, DG, TJC, MR, PBJ; grant number 088869/Z/09/Z), and grant MIMOmics of the European Union’s Seventh Framework Programme FP7-Health-F5- 2012 (MKX, RT, JDH; grant number 305280). PBJ acknowledges financial support from the NIHR CLAHRC East of England. MR is supported by the Medical Research Council (grant code MC_UU_12019/3, MC_UU_12019/1).",
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Xu, MK, Gaysina, D, Tsonaka, R, Morin, AJS, Croudace, TJ, Barnett, JH, Houwing-Duistermaat, J, Richards, M, Jones, PB & LHA Genetics Group 2017, 'Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation', Frontiers in Psychology, vol. 8, 1736, pp. 1-13. https://doi.org/10.3389/fpsyg.2017.01736

Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood : A Latent Variable Investigation. / Xu, Man K.; Gaysina, Darya; Tsonaka, Roula; Morin, Alexandre J. S.; Croudace, Tim J.; Barnett, Jennifer H.; Houwing-Duistermaat, Jeanine; Richards, Marcus; Jones, Peter B.; LHA Genetics Group.

In: Frontiers in Psychology, Vol. 8, 1736, 11.10.2017, p. 1-13.

Research output: Contribution to journalArticle

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T1 - Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood

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AU - Xu, Man K.

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AU - Tsonaka, Roula

AU - Morin, Alexandre J. S.

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AU - Houwing-Duistermaat, Jeanine

AU - Richards, Marcus

AU - Jones, Peter B.

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N1 - This work was supported by the Wellcome Trust grant (MKX, DG, TJC, MR, PBJ; grant number 088869/Z/09/Z), and grant MIMOmics of the European Union’s Seventh Framework Programme FP7-Health-F5- 2012 (MKX, RT, JDH; grant number 305280). PBJ acknowledges financial support from the NIHR CLAHRC East of England. MR is supported by the Medical Research Council (grant code MC_UU_12019/3, MC_UU_12019/1).

PY - 2017/10/11

Y1 - 2017/10/11

N2 - Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1160 male and 1180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β=‐0.167; CI: ‐0.289, ‐0.045; p=0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β=0.197; CI: 0.067, 0.328; p= 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modelling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.

AB - Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1160 male and 1180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β=‐0.167; CI: ‐0.289, ‐0.045; p=0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β=0.197; CI: 0.067, 0.328; p= 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modelling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.

KW - latent variable

KW - MAOA

KW - personality

KW - development

KW - adolescents

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