Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures

C. L. Campbell (Lead / Corresponding author), K. Wood, C. T. A. Brown, H. Moseley

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    6 Citations (Scopus)
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    Abstract

    We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.

    Original languageEnglish
    Pages (from-to)4840-4854
    Number of pages15
    JournalPhysics in Medicine and Biology
    Volume61
    Issue number13
    DOIs
    Publication statusPublished - 7 Jun 2016

    Keywords

    • Monte Carlo modelling
    • Photodynamic therapy
    • three dimensional modelling

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