TY - JOUR
T1 - Morbidity associated with primary hyperparathyroidism
T2 - A population-based study with a sub-analysis on Vitamin D
AU - Soto-Pedre, Enrique
AU - Lin, Yeun Yi
AU - Soto-Hernaez, Jimena
AU - Newey, Paul J.
AU - Leese, Graham P.
N1 - Funding Information:
The study was supported by the NHS Tayside Research Endowments.
Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2023/2/22
Y1 - 2023/2/22
N2 - Objective: The aim of this study was to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT).Design: A population-based retrospective matched cohort study.Methods: Data linkage of biochemistry, hospital admissions, prescribing, imaging, pathology and deaths was used to identify patients across the region of Tayside who had Primary hyperparathyroidism from 1997 to 2019. Cox proportional hazards models and Hazards Ratios (HR) were used to explore the relationship between exposure to PHPT and several clinical outcomes. Comparisons were made with an age and gender matched cohort.Results: In 11,616 people with PHPT (66.8% female), with mean follow up of 8.8 years there was an adjusted HR of death of 2.05 (95% CI 1.97-2.13) for those exposed to PHPT. There was also an increased risk of cardiovascular disease (HR= 1.34, 95%CI 1.24-1.45), cerebrovascular disease (HR=1.29, 95%CI 1.15-1.45), diabetes (HR=1.39, 95%CI 1.26-1.54), renal stones (HR=3.02, 95%CI 2.19- 4.17) and osteoporosis (HR=1.31, 95%CI 1.16- 1.49). Following adjustment for serum Vitamin D concentrations (n=2748), increased risks for death, diabetes, renal stones, and osteoporosis persisted, but not for cardiovascular or cerebrovascular disease.Conclusions: In a large population-based study, PHPT was associated with death, diabetes, renal stones and osteoporosis that was independent of serum vitamin D concentration.
AB - Objective: The aim of this study was to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT).Design: A population-based retrospective matched cohort study.Methods: Data linkage of biochemistry, hospital admissions, prescribing, imaging, pathology and deaths was used to identify patients across the region of Tayside who had Primary hyperparathyroidism from 1997 to 2019. Cox proportional hazards models and Hazards Ratios (HR) were used to explore the relationship between exposure to PHPT and several clinical outcomes. Comparisons were made with an age and gender matched cohort.Results: In 11,616 people with PHPT (66.8% female), with mean follow up of 8.8 years there was an adjusted HR of death of 2.05 (95% CI 1.97-2.13) for those exposed to PHPT. There was also an increased risk of cardiovascular disease (HR= 1.34, 95%CI 1.24-1.45), cerebrovascular disease (HR=1.29, 95%CI 1.15-1.45), diabetes (HR=1.39, 95%CI 1.26-1.54), renal stones (HR=3.02, 95%CI 2.19- 4.17) and osteoporosis (HR=1.31, 95%CI 1.16- 1.49). Following adjustment for serum Vitamin D concentrations (n=2748), increased risks for death, diabetes, renal stones, and osteoporosis persisted, but not for cardiovascular or cerebrovascular disease.Conclusions: In a large population-based study, PHPT was associated with death, diabetes, renal stones and osteoporosis that was independent of serum vitamin D concentration.
KW - Primary hyperparathyroidism
KW - Vitamin D
KW - calcium
KW - mortality
U2 - 10.1210/clinem/dgad103
DO - 10.1210/clinem/dgad103
M3 - Article
C2 - 36810667
SN - 0021-972X
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
ER -
