Morbidity associated with primary hyperparathyroidism: A population-based study with a sub-analysis on Vitamin D

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Abstract

Objective: The aim of this study was to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT).

Design: A population-based retrospective matched cohort study.

Methods: Data linkage of biochemistry, hospital admissions, prescribing, imaging, pathology and deaths was used to identify patients across the region of Tayside who had Primary hyperparathyroidism from 1997 to 2019. Cox proportional hazards models and Hazards Ratios (HR) were used to explore the relationship between exposure to PHPT and several clinical outcomes. Comparisons were made with an age and gender matched cohort.

Results: In 11,616 people with PHPT (66.8% female), with mean follow up of 8.8 years there was an adjusted HR of death of 2.05 (95% CI 1.97-2.13) for those exposed to PHPT. There was also an increased risk of cardiovascular disease (HR= 1.34, 95%CI 1.24-1.45), cerebrovascular disease (HR=1.29, 95%CI 1.15-1.45), diabetes (HR=1.39, 95%CI 1.26-1.54), renal stones (HR=3.02, 95%CI 2.19- 4.17) and osteoporosis (HR=1.31, 95%CI 1.16- 1.49). Following adjustment for serum Vitamin D concentrations (n=2748), increased risks for death, diabetes, renal stones, and osteoporosis persisted, but not for cardiovascular or cerebrovascular disease.

Conclusions: In a large population-based study, PHPT was associated with death, diabetes, renal stones and osteoporosis that was independent of serum vitamin D concentration.

Original languageEnglish
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Early online date22 Feb 2023
DOIs
Publication statusE-pub ahead of print - 22 Feb 2023

Keywords

  • Primary hyperparathyroidism
  • Vitamin D
  • calcium
  • mortality

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