More than skin deep: atherosclerosis as a systemic manifestation of psoriasis

A. B. Alexandroff, M. Pauriah, R. D. R. Camp, Chim Lang, Allan Struthers, D. J. Armstrong

    Research output: Contribution to journalReview articlepeer-review

    104 Citations (Scopus)

    Abstract

    There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.

    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalBritish Journal of Dermatology
    Volume161
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Keywords

    • atherosclerosis
    • cardiovascular disease
    • metabolic syndrome
    • psoriasis
    • tumour necrosis factor-alpha
    • NECROSIS-FACTOR-ALPHA
    • REGULATORY T-CELLS
    • CORONARY-ARTERY-DISEASE
    • EVIDENT CARDIOVASCULAR-DISEASE
    • PLACEBO-CONTROLLED TRIAL
    • TOLL-LIKE-RECEPTORS
    • RHEUMATOID-ARTHRITIS
    • RISK-FACTORS
    • MYOCARDIAL-INFARCTION
    • ENDOTHELIAL FUNCTION

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