More than skin deep

atherosclerosis as a systemic manifestation of psoriasis

A. B. Alexandroff, M. Pauriah, R. D. R. Camp, Chim Lang, Allan Struthers, D. J. Armstrong

    Research output: Contribution to journalReview article

    96 Citations (Scopus)

    Abstract

    There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.

    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalBritish Journal of Dermatology
    Volume161
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Keywords

    • atherosclerosis
    • cardiovascular disease
    • metabolic syndrome
    • psoriasis
    • tumour necrosis factor-alpha
    • NECROSIS-FACTOR-ALPHA
    • REGULATORY T-CELLS
    • CORONARY-ARTERY-DISEASE
    • EVIDENT CARDIOVASCULAR-DISEASE
    • PLACEBO-CONTROLLED TRIAL
    • TOLL-LIKE-RECEPTORS
    • RHEUMATOID-ARTHRITIS
    • RISK-FACTORS
    • MYOCARDIAL-INFARCTION
    • ENDOTHELIAL FUNCTION

    Cite this

    Alexandroff, A. B. ; Pauriah, M. ; Camp, R. D. R. ; Lang, Chim ; Struthers, Allan ; Armstrong, D. J. / More than skin deep : atherosclerosis as a systemic manifestation of psoriasis. In: British Journal of Dermatology. 2009 ; Vol. 161, No. 1. pp. 1-7.
    @article{f6653bef0b534c579a3fe4331751b4d4,
    title = "More than skin deep: atherosclerosis as a systemic manifestation of psoriasis",
    abstract = "There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.",
    keywords = "atherosclerosis, cardiovascular disease, metabolic syndrome, psoriasis, tumour necrosis factor-alpha, NECROSIS-FACTOR-ALPHA, REGULATORY T-CELLS, CORONARY-ARTERY-DISEASE, EVIDENT CARDIOVASCULAR-DISEASE, PLACEBO-CONTROLLED TRIAL, TOLL-LIKE-RECEPTORS, RHEUMATOID-ARTHRITIS, RISK-FACTORS, MYOCARDIAL-INFARCTION, ENDOTHELIAL FUNCTION",
    author = "Alexandroff, {A. B.} and M. Pauriah and Camp, {R. D. R.} and Chim Lang and Allan Struthers and Armstrong, {D. J.}",
    year = "2009",
    doi = "10.1111/j.1365-2133.2009.09281.x",
    language = "English",
    volume = "161",
    pages = "1--7",
    journal = "British Journal of Dermatology",
    issn = "0007-0963",
    publisher = "Wiley",
    number = "1",

    }

    More than skin deep : atherosclerosis as a systemic manifestation of psoriasis. / Alexandroff, A. B.; Pauriah, M.; Camp, R. D. R.; Lang, Chim; Struthers, Allan; Armstrong, D. J.

    In: British Journal of Dermatology, Vol. 161, No. 1, 2009, p. 1-7.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - More than skin deep

    T2 - atherosclerosis as a systemic manifestation of psoriasis

    AU - Alexandroff, A. B.

    AU - Pauriah, M.

    AU - Camp, R. D. R.

    AU - Lang, Chim

    AU - Struthers, Allan

    AU - Armstrong, D. J.

    PY - 2009

    Y1 - 2009

    N2 - There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.

    AB - There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.

    KW - atherosclerosis

    KW - cardiovascular disease

    KW - metabolic syndrome

    KW - psoriasis

    KW - tumour necrosis factor-alpha

    KW - NECROSIS-FACTOR-ALPHA

    KW - REGULATORY T-CELLS

    KW - CORONARY-ARTERY-DISEASE

    KW - EVIDENT CARDIOVASCULAR-DISEASE

    KW - PLACEBO-CONTROLLED TRIAL

    KW - TOLL-LIKE-RECEPTORS

    KW - RHEUMATOID-ARTHRITIS

    KW - RISK-FACTORS

    KW - MYOCARDIAL-INFARCTION

    KW - ENDOTHELIAL FUNCTION

    U2 - 10.1111/j.1365-2133.2009.09281.x

    DO - 10.1111/j.1365-2133.2009.09281.x

    M3 - Review article

    VL - 161

    SP - 1

    EP - 7

    JO - British Journal of Dermatology

    JF - British Journal of Dermatology

    SN - 0007-0963

    IS - 1

    ER -