Abstract
There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | British Journal of Dermatology |
| Volume | 161 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- atherosclerosis
- cardiovascular disease
- metabolic syndrome
- psoriasis
- tumour necrosis factor-alpha
- NECROSIS-FACTOR-ALPHA
- REGULATORY T-CELLS
- CORONARY-ARTERY-DISEASE
- EVIDENT CARDIOVASCULAR-DISEASE
- PLACEBO-CONTROLLED TRIAL
- TOLL-LIKE-RECEPTORS
- RHEUMATOID-ARTHRITIS
- RISK-FACTORS
- MYOCARDIAL-INFARCTION
- ENDOTHELIAL FUNCTION
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