Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography: Feasibility Study

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

HIFU is a noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the ultrasound focus to kill the targeted tissue for disease treatment purpose. The feasibility of monitoring and guiding HIFU treatment using the optical property change in the superficial area of biological tissue is explored. Ex-vivo bovine liver tissue was treated using different HIFU doses (same energy level for Os, 1s, 5s, 9s) in this research. The 3D structure volume and elastogram were acquired in the lesion area after HIFU treatment. The OCT structure images clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time, which agree well with the elastography results. The average OCT signal intensity and OCT signal attenuation ratio in the lesion area grows as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment monitoring, but also to be used for high-precision-demanded diseases treatment monitoring, e.g. nervous disease treatment monitoring.

Original languageEnglish
Title of host publication2018 IEEE International Ultrasonics Symposium, IUS 2018
PublisherIEEE Computer Society
Volume2018-October
ISBN (Electronic)9781538634257
DOIs
Publication statusPublished - 17 Dec 2018
Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Kobe, Japan
Duration: 22 Oct 201825 Oct 2018

Conference

Conference2018 IEEE International Ultrasonics Symposium, IUS 2018
CountryJapan
CityKobe
Period22/10/1825/10/18

Fingerprint

tomography
lesions
acoustics
liver
needles
attenuation
energy levels
optical properties
dosage
probes

Keywords

  • ex-vivo bovine liver
  • high intensity focused ultrasound (HIFU)
  • optical coherence tomography
  • optical property
  • shear wave elastography
  • treatment monitoring

Cite this

Zhou, K., Wang, Y., Wang, G., Feng, K., Li, F., Li, C., & Huang, Z. (2018). Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography: Feasibility Study. In 2018 IEEE International Ultrasonics Symposium, IUS 2018 (Vol. 2018-October). [8580088] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2018.8580088
Zhou, Kanheng ; Wang, Yan ; Wang, Guan ; Feng, Kairui ; Li, Faqi ; Li, Chunhui ; Huang, Zhihonz. / Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography : Feasibility Study. 2018 IEEE International Ultrasonics Symposium, IUS 2018. Vol. 2018-October IEEE Computer Society, 2018.
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title = "Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography: Feasibility Study",
abstract = "HIFU is a noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the ultrasound focus to kill the targeted tissue for disease treatment purpose. The feasibility of monitoring and guiding HIFU treatment using the optical property change in the superficial area of biological tissue is explored. Ex-vivo bovine liver tissue was treated using different HIFU doses (same energy level for Os, 1s, 5s, 9s) in this research. The 3D structure volume and elastogram were acquired in the lesion area after HIFU treatment. The OCT structure images clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time, which agree well with the elastography results. The average OCT signal intensity and OCT signal attenuation ratio in the lesion area grows as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment monitoring, but also to be used for high-precision-demanded diseases treatment monitoring, e.g. nervous disease treatment monitoring.",
keywords = "ex-vivo bovine liver, high intensity focused ultrasound (HIFU), optical coherence tomography, optical property, shear wave elastography, treatment monitoring",
author = "Kanheng Zhou and Yan Wang and Guan Wang and Kairui Feng and Faqi Li and Chunhui Li and Zhihonz Huang",
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Zhou, K, Wang, Y, Wang, G, Feng, K, Li, F, Li, C & Huang, Z 2018, Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography: Feasibility Study. in 2018 IEEE International Ultrasonics Symposium, IUS 2018. vol. 2018-October, 8580088, IEEE Computer Society, 2018 IEEE International Ultrasonics Symposium, IUS 2018, Kobe, Japan, 22/10/18. https://doi.org/10.1109/ULTSYM.2018.8580088

Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography : Feasibility Study. / Zhou, Kanheng; Wang, Yan; Wang, Guan; Feng, Kairui; Li, Faqi; Li, Chunhui; Huang, Zhihonz.

2018 IEEE International Ultrasonics Symposium, IUS 2018. Vol. 2018-October IEEE Computer Society, 2018. 8580088.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Huang, Zhihonz

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AB - HIFU is a noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the ultrasound focus to kill the targeted tissue for disease treatment purpose. The feasibility of monitoring and guiding HIFU treatment using the optical property change in the superficial area of biological tissue is explored. Ex-vivo bovine liver tissue was treated using different HIFU doses (same energy level for Os, 1s, 5s, 9s) in this research. The 3D structure volume and elastogram were acquired in the lesion area after HIFU treatment. The OCT structure images clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time, which agree well with the elastography results. The average OCT signal intensity and OCT signal attenuation ratio in the lesion area grows as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment monitoring, but also to be used for high-precision-demanded diseases treatment monitoring, e.g. nervous disease treatment monitoring.

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Zhou K, Wang Y, Wang G, Feng K, Li F, Li C et al. Mornitoring High Intensity Focused Ultrasound (HIFU) Treatment Using Optical Coherence Tomography: Feasibility Study. In 2018 IEEE International Ultrasonics Symposium, IUS 2018. Vol. 2018-October. IEEE Computer Society. 2018. 8580088 https://doi.org/10.1109/ULTSYM.2018.8580088