Morpholino compounds, uses and methods

Jeremy Besnard (Inventor), Andrew Hopkins (Inventor), Ian Gilbert (Inventor), Gian Filippo Ruda (Inventor), Keren Abecassis (Inventor)

    Research output: Patent


    The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HTla. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.
    Original languageEnglish
    Patent numberPCT/GB2012/051194
    Filing date25/05/12
    Publication statusPublished - 29 Nov 2012


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